中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2013年
9期
671-673
,共3页
杨智%涂颖%尹锐%杨慧兰%王玮蓁%李利%林琳%刘仲荣%李咏
楊智%塗穎%尹銳%楊慧蘭%王瑋蓁%李利%林琳%劉仲榮%李詠
양지%도영%윤예%양혜란%왕위진%리리%림림%류중영%리영
目的 探讨透明质酸修护贴敷料对强脉冲光治疗后面部皮肤修复的安全性.方法 多中心、随机对照方法,对298例强脉冲光术后患者的面部皮肤外用透明质酸修护贴敷料或生理氯化钠溶液面膜,并对其中68例患者第3、7、14天进行皮肤生理功能测试,同时对所有患者的结痂脱落情况、患者对该产品的满意度及安全性进行评价.结果 治疗14d后,在68例患者中,试验组角质层含水量为25.32±4.14,经表皮水分丢失为14.08±3.32,与治疗前及对照组比较,差异有统计学意义(P<0.01),皮肤油脂含量差异无统计学意义.所有患者中,试验组3d内第1块结痂脱落患者例数和7d内结痂完全脱落例数与对照组比较,差异均有统计学意义(x2=7.774,P< 0.01;x2=4.692,P< 0.05),两组患者对产品自评,差异均有统计学意义(P<0.05),观察期间均未出现不良反应.结论 透明质酸修护贴敷料对强脉冲光术后面部皮肤有辅助作用,有助于恢复皮肤屏障功能,安全性好.
目的 探討透明質痠脩護貼敷料對彊脈遲光治療後麵部皮膚脩複的安全性.方法 多中心、隨機對照方法,對298例彊脈遲光術後患者的麵部皮膚外用透明質痠脩護貼敷料或生理氯化鈉溶液麵膜,併對其中68例患者第3、7、14天進行皮膚生理功能測試,同時對所有患者的結痂脫落情況、患者對該產品的滿意度及安全性進行評價.結果 治療14d後,在68例患者中,試驗組角質層含水量為25.32±4.14,經錶皮水分丟失為14.08±3.32,與治療前及對照組比較,差異有統計學意義(P<0.01),皮膚油脂含量差異無統計學意義.所有患者中,試驗組3d內第1塊結痂脫落患者例數和7d內結痂完全脫落例數與對照組比較,差異均有統計學意義(x2=7.774,P< 0.01;x2=4.692,P< 0.05),兩組患者對產品自評,差異均有統計學意義(P<0.05),觀察期間均未齣現不良反應.結論 透明質痠脩護貼敷料對彊脈遲光術後麵部皮膚有輔助作用,有助于恢複皮膚屏障功能,安全性好.
목적 탐토투명질산수호첩부료대강맥충광치료후면부피부수복적안전성.방법 다중심、수궤대조방법,대298례강맥충광술후환자적면부피부외용투명질산수호첩부료혹생리록화납용액면막,병대기중68례환자제3、7、14천진행피부생리공능측시,동시대소유환자적결가탈락정황、환자대해산품적만의도급안전성진행평개.결과 치료14d후,재68례환자중,시험조각질층함수량위25.32±4.14,경표피수분주실위14.08±3.32,여치료전급대조조비교,차이유통계학의의(P<0.01),피부유지함량차이무통계학의의.소유환자중,시험조3d내제1괴결가탈락환자례수화7d내결가완전탈락례수여대조조비교,차이균유통계학의의(x2=7.774,P< 0.01;x2=4.692,P< 0.05),량조환자대산품자평,차이균유통계학의의(P<0.05),관찰기간균미출현불량반응.결론 투명질산수호첩부료대강맥충광술후면부피부유보조작용,유조우회복피부병장공능,안전성호.
Objective To evaluate the safety of a hyaluronic acid-containing dressing for wound healing of facial skin in patients with freckles after intensive pulsed light (IPL) therapy.Methods A multicenter,randomized,open,controlled clinical trial was conducted.A total of 298 IPL-treated patients with freckles were recruited into this study.After IPL therapy,all the patients were randomly divided into two groups to be topically treated with a hyaluronic acid-containing dressing (experiment group) or a sodium chloride physiological solutioncontaining face mask (control group).Skin physiological parameters,including sebum content,water content in stratum corneum,and transepidermal water loss,were invasively measured at the baseline,on day 3,7 and 14 after the start of topical treatment.The formation and desquamation of irradiation-induced crusts were observed,the degree of patient satisfaction was evaluated,and adverse reactions were recorded.Results The water content in stratum corneum and transepidermal water loss were (25.32 ± 4.14) % and (14.08 ± 3.32) g·cm-2·h-1,respectively,in the experimental group on day 14,significantly different from those before treatment (both P<0.01) and those in the control group on day 14 (both P < 0.01).Skin sebum content in the experiment group showed no significant changes during the 14-day treatment (P > 0.05),and was similar to that in the control group on day 14 (P > 0.05).The percentage of patients experiencing the initial desquamation of crusts within three days and that experiencing complete desquamation of crusts within seven days were significantly different between the experiment group and control group (x2 =7.774,P < 0.01; x2 =4.692,P < 0.05).Statistical differences were observed in the degree of patient satisfaction between the two groups (P < 0.05).No adverse reactions were reported during the trial.Conclusion The hyaluronic acid-containing dressing can restore skin barrier function with a good safety profile,and may serve as an adjuvant therapy for wound healing of facial skin after IPL irradiation.