CAJ | 학술논문

目的探讨含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液改善寻常痤疮的安全性.方法多中心、随机、开放对照研究,分为观察组及对照组各80例.每天早晚各1次,在使用薇诺娜洁面泡沫清洁面部后,观察组在痤疮皮损处使用含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液,对照组在皮损处外用含木瓜蛋白酶活性成分、维生素B3、马齿苋提取液、水杨酸衍生物的薇诺娜清痘修复精华液.分别观察观察组和对照组使用前后皮损改善情况.结果共完成149例,脱落11例,完成实验中,观察组73例,对照组76例.使用受试品14 d,28 d,使用前后炎性皮损及总皮损数较首诊日均有明显改善(P＜0.05),观察组与对照组有效率比较,差异无统计学意义.结论含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液能辅助改善痤疮皮损.
목적 탐토함중루、마치현제취물、투명질산납적청두수복정화액개선심상좌창적안전성.방법 다중심、수궤、개방대조연구,분위관찰조급대조조각80례.매천조만각1차,재사용미낙나길면포말청길면부후,관찰조재좌창피손처사용함중루、마치현제취물、투명질산납적청두수복정화액,대조조재피손처외용함목과단백매활성성분、유생소B3、마치현제취액、수양산연생물적미낙나청두수복정화액.분별관찰관찰조화대조조사용전후피손개선정황.결과 공완성149례,탈락11례,완성실험중,관찰조73례,대조조76례.사용수시품14 d,28 d,사용전후염성피손급총피손수교수진일균유명현개선(P＜0.05),관찰조여대조조유효솔비교,차이무통계학의의.결론 함중루、마치현제취물、투명질산납적청두수복정화액능보조개선좌창피손.
Objective To evaluate the safety of Qingdou Xiufu Jinghua Ye,a skin care product containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate,in the improvement of acne vulgaris.Methods A multicenter,randomized,open-label,controlled study was conducted.Totally,160 patients with acne vulgaris were equally classified into two groups to topically apply the modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate (experiment group) or the original Qingdou Xiufu Jinghua Ye containing papain,vitamin B3,extract of purslane,and salicylic acid derivate (control group),twice a day after face washing with a commercial foaming face wash.The number of acne lesions was calculated at the baseline,on day 7,14 and 28 after the start of intervention.Results Finally,11 patients were lost to follow-up,and 149 patients completed the trial,including 73 patients in the experiment group and 76 patients in the control group.The number of inflammatory lesions and total lesions significantly decreased in both groups on day 14 and 28 compared with that before intervention (all P ＜ 0.05).No statistical difference was observed in the response rate between the two groups at any of the three time points after treatment (all P ＞0.05).Conclusion The topical application of modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate is beneficial to the improvement of acne vulgaris.