中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2013年
12期
892-895
,共4页
目的 评价头孢曲松治疗早期梅毒的临床疗效.方法 检索中英文文献数据库1985-2012年公开发表的有关头孢曲松治疗早期梅毒疗效研究的论著,使用Jadad评分对文献质量进行评价并纳入符合要求的文献,使用Stata 12.0软件进行Meta分析.结果 共纳入符合条件的文献14篇,其中高质量文献5篇.以头孢曲松治疗有效率和青霉素治疗有效率的率比(RR值)为指标进行Meta分析.随访6个月、12个月、24个月时,两种药物的疗效差异无统计学意义.随访12个月时,头孢曲松组的有效率为92.3％(95％ CI88.5％ ～ 96.1％),青霉素组有效率为90.4％(95％ CI87.4％～94.4％).漏斗图结果近似对称,发表偏倚较小.结论 头孢曲松可作为治疗早期梅毒的替代方案,疗效确切.有必要开展多中心大样本的随机对照试验以优化治疗剂量与确定疗程.
目的 評價頭孢麯鬆治療早期梅毒的臨床療效.方法 檢索中英文文獻數據庫1985-2012年公開髮錶的有關頭孢麯鬆治療早期梅毒療效研究的論著,使用Jadad評分對文獻質量進行評價併納入符閤要求的文獻,使用Stata 12.0軟件進行Meta分析.結果 共納入符閤條件的文獻14篇,其中高質量文獻5篇.以頭孢麯鬆治療有效率和青黴素治療有效率的率比(RR值)為指標進行Meta分析.隨訪6箇月、12箇月、24箇月時,兩種藥物的療效差異無統計學意義.隨訪12箇月時,頭孢麯鬆組的有效率為92.3％(95％ CI88.5％ ～ 96.1％),青黴素組有效率為90.4％(95％ CI87.4％～94.4％).漏鬥圖結果近似對稱,髮錶偏倚較小.結論 頭孢麯鬆可作為治療早期梅毒的替代方案,療效確切.有必要開展多中心大樣本的隨機對照試驗以優化治療劑量與確定療程.
목적 평개두포곡송치료조기매독적림상료효.방법 검색중영문문헌수거고1985-2012년공개발표적유관두포곡송치료조기매독료효연구적론저,사용Jadad평분대문헌질량진행평개병납입부합요구적문헌,사용Stata 12.0연건진행Meta분석.결과 공납입부합조건적문헌14편,기중고질량문헌5편.이두포곡송치료유효솔화청매소치료유효솔적솔비(RR치)위지표진행Meta분석.수방6개월、12개월、24개월시,량충약물적료효차이무통계학의의.수방12개월시,두포곡송조적유효솔위92.3％(95％ CI88.5％ ～ 96.1％),청매소조유효솔위90.4％(95％ CI87.4％～94.4％).루두도결과근사대칭,발표편의교소.결론 두포곡송가작위치료조기매독적체대방안,료효학절.유필요개전다중심대양본적수궤대조시험이우화치료제량여학정료정.
Objective To retrieve clinical evidence for the efficacy of ceftriaxone in the treatment of early syphilis.Methods Several international and national medical databases were used to search original articles published from 1985 to 2012 and reporting the efficacy of ceftriaxone or penicillin for the treatment of early syphilis.Randomized controlled trials (RCTs) and clinical controlled trials (CCTs) were identified and retrieved.The quality of studies was assessed using the Jadad scale.Eligible studies were selected according to an established strategy.A meta-analysis was performed by the Stata software version 12.0.Results A total of 14 RCTs or CCTs were eligible for this meta-analysis,including five high-quality trials.Response rate ratios were calculated for ceftriaxone-treated patients compared with penicillin-treated patients.The meta-analysis showed no significant difference in the efficacy between ceftriaxone and penicillin at 6-,12-and 24-month follow-up visits.The response rate was 92.3％ (95％ CI:88.5％-96.1％) and 90.4％ (95％ CI:87.4％-94.4％) in ceftriaxone-and penicillintreated patients respectively at the 12-month follow-up visit.Funnel plots were approximately symmetrical,indicating little publication bias.Conclusions Ceftriaxone may serve as an alternative treatment for early syphilis with reliable efficacy.However,multi-centered RCTs with large sample sizes are still needed to optimize the therapeutic dose and course of ceftriaxone for early syphilis.
