CAJ | 학술논문

目的探讨乳头汗管瘤样腺瘤的临床病理学特征.方法对4例乳头汗管瘤样腺瘤进行临床病理分析,并结合文献讨论其诊断与鉴别诊断特点.结果 4例患者中,女3例,男1例,平均发病年龄42岁,病程3个月至10年.临床均表现为无症状的皮下肿块,女性患者皮损位于乳晕,男性患者位于右腋下.皮损组织病理显示,肿瘤位于真皮及皮下,可见上皮细胞呈小管、条索状,向周围硬化的间质内浸润,部分小管呈“逗点/蝌蚪”状,并见角囊肿形成;免疫组化染色,肿瘤表达细胞角蛋白(CK)、CK5/6;不表达雌激素受体、孕激素受体、CerbB2、CK8/18、P53、囊泡病液体蛋白15;小管周围肌上皮细胞表达P63和平滑肌肌动蛋白;细胞核增殖相关抗原Ki67阳性率约1％.结论乳头汗管瘤样腺瘤易与多种乳腺良恶性肿瘤相混淆.
목적 탐토유두한관류양선류적림상병이학특정.방법 대4례유두한관류양선류진행림상병리분석,병결합문헌토론기진단여감별진단특점.결과 4례환자중,녀3례,남1례,평균발병년령42세,병정3개월지10년.림상균표현위무증상적피하종괴,녀성환자피손위우유훈,남성환자위우우액하.피손조직병리현시,종류위우진피급피하,가견상피세포정소관、조색상,향주위경화적간질내침윤,부분소관정“두점/과두”상,병견각낭종형성;면역조화염색,종류표체세포각단백(CK)、CK5/6;불표체자격소수체、잉격소수체、CerbB2、CK8/18、P53、낭포병액체단백15;소관주위기상피세포표체P63화평활기기동단백;세포핵증식상관항원Ki67양성솔약1％.결론 유두한관류양선류역여다충유선량악성종류상혼효.
Objective To study the clinicopathological features of syringomatous adenoma of the nipple (SAN).Methods The clinical,histopathological and immunohistochemical findings of four cases of SAN were described,with a review of the literature.The diagnosis and differential diagnosis of SAN were also discussed.Results Among the four patients,three were female,and one was male.The mean age at onset was 42 years,and clinical course ranged from 3 months to 10 years.Clinically,SAN was manifested as an asymptomatic subcutaneous nodule,which was located in the areola of breast of female patients and in the right armpit of the male patient.Histopathologically,the tumor was located in the dermis and subcutaneous tissue,composed of nests and cords of epithelial cells forming tubular structures and infiltrating the indurated stroma between smooth muscle bundles.These tubules were lined by two layers of cells and displayed a "comma" or "tadpole" shape.Keratotic microcysts were seen.Immunohistochemically,the tumor cells stained positive for cytokeratin,cytokeratin 5/6,Ki67 (1％),but negative for estrogen receptor,progesterone receptor,CerbB2,cytokeratin 8/18,P53 and gross cystic disease fluid protein-15 (GCDFP-15).The peritubular myoepithelial cells expressed P63 and smooth muscle actin (SMA).Conclusions SAN is a rare benign tumor,which is often confused with some benign and malignant carcinomas of the breast.