中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2012年
12期
966-969
,共4页
秦兴雷%鲁敏%王作仁%贾萌%王林%张云锋%李珂%薛焕洲
秦興雷%魯敏%王作仁%賈萌%王林%張雲鋒%李珂%薛煥洲
진흥뢰%로민%왕작인%가맹%왕림%장운봉%리가%설환주
胆管肿瘤%胆道外科手术%预后
膽管腫瘤%膽道外科手術%預後
담관종류%담도외과수술%예후
Common bile duct neoplasms%Biliary tract surgical procedures%Prognosis
目的 探讨肝门部胆管癌的临床特征、治疗方法对远期生存率的影响.方法 对1995 —2005年收治的98例肝门部胆管癌的临床特点、诊断及随访结果进行回顾性分析,并将手术方式和治疗效果进行对比研究.根据数据类型分别进行x2检验、t检验,生存率计算采用Kaplan-Meier 法,并作log-rank检验.结果 83例施行了外科手术,15例施行保守治疗.83例中行根治性切除术者33例,姑息性切除术者16例,内或外引流术者34例.肝门部胆管癌切除者1、3、5年生存率分别为79％、42％、17％,其中根治性切除1、3、5年生存率分别为88％、54％、24％；姑息性切除1、3年生存率分别为55％、9％,无5年存活者.根治性切除、姑息性切除生存率差异有统计学意义(log-rank test,P＜0.001).结论 根治性切除是提高肝门部胆管癌远期生存率及改善生活质量的有效手段,早期诊断和治疗是提高远期疗效的关键.
目的 探討肝門部膽管癌的臨床特徵、治療方法對遠期生存率的影響.方法 對1995 —2005年收治的98例肝門部膽管癌的臨床特點、診斷及隨訪結果進行迴顧性分析,併將手術方式和治療效果進行對比研究.根據數據類型分彆進行x2檢驗、t檢驗,生存率計算採用Kaplan-Meier 法,併作log-rank檢驗.結果 83例施行瞭外科手術,15例施行保守治療.83例中行根治性切除術者33例,姑息性切除術者16例,內或外引流術者34例.肝門部膽管癌切除者1、3、5年生存率分彆為79％、42％、17％,其中根治性切除1、3、5年生存率分彆為88％、54％、24％；姑息性切除1、3年生存率分彆為55％、9％,無5年存活者.根治性切除、姑息性切除生存率差異有統計學意義(log-rank test,P＜0.001).結論 根治性切除是提高肝門部膽管癌遠期生存率及改善生活質量的有效手段,早期診斷和治療是提高遠期療效的關鍵.
목적 탐토간문부담관암적림상특정、치료방법대원기생존솔적영향.방법 대1995 —2005년수치적98례간문부담관암적림상특점、진단급수방결과진행회고성분석,병장수술방식화치료효과진행대비연구.근거수거류형분별진행x2검험、t검험,생존솔계산채용Kaplan-Meier 법,병작log-rank검험.결과 83례시행료외과수술,15례시행보수치료.83례중행근치성절제술자33례,고식성절제술자16례,내혹외인류술자34례.간문부담관암절제자1、3、5년생존솔분별위79％、42％、17％,기중근치성절제1、3、5년생존솔분별위88％、54％、24％；고식성절제1、3년생존솔분별위55％、9％,무5년존활자.근치성절제、고식성절제생존솔차이유통계학의의(log-rank test,P＜0.001).결론 근치성절제시제고간문부담관암원기생존솔급개선생활질량적유효수단,조기진단화치료시제고원기료효적관건.
Objective To investigate the clinical features and the prognosis after surgical treatment for hilar cholangiocarcinoma (HCC).Methods The surgical therapy and follow-up result were retrospectively analyzed on 98 cases of hilar cholangiocarcinoma admitted into our hospital from January 1995 to January 2005.Differences between groups were evaluated using Chi-square analysis or Student t-test according to the data type.Survival rate was calculated with Kaplan-Meier method,and using the log-rank test.Results Among 98 patients,83 patients underwent surgical treatment (radical resection in 33,palliative resection in 16,and nonresectional internal or external bile duct drainage in 34),15 patients underwent conservative therapy.The 1-,3-,5-year survival rates were 79％,42％,and 17％ in the resection group and 88％,54％,and 24％ in the radical resection group,respectively.The 1-,3-year survival rates were 55％,and 9％ in palliative resection group,respectively,and none of the patient survived for over 5 years.There were significant differences in the survival rate among the radical resection group and the palliative resection group (log-rank test,P ＜ 0.001).Conclusions Radical resection improves the prognosis of hilar cholangiocarcinoma.
