CAJ | 학술논문

目的探讨脾动脉缩窄对大鼠肝硬化进程的影响.方法将96只SD大鼠随机分3组,对照组仅行开腹术；切脾组开腹行脾脏切除术；脾动脉缩窄组开腹行脾动脉缩窄术,然后腹腔注射硫代乙酰胺诱导肝硬化模型.定期处死一定数量的大鼠,动态观察大鼠血常规、肝功能、肝组织病理改变及血清Tuftsin水平变化.结果术后对照组大鼠白细胞、红细胞和血小板逐渐下降(P＜0.05),而切脾组和脾动脉缩窄组未见明显变化(P＞0.05)；切脾组与脾动脉缩窄组的肝功能损伤和肝硬化程度较同期对照组相比轻(P＜0.05)；脾动脉缩窄组血清Tuftsin水平与对照组比较差异无统计学意义(P＞0.05),而切脾组Tuftsin水平显著下降(P＜0.05).结论脾动脉缩窄术和切脾术均能有效地防止脾功能亢进的发生,从而延缓肝硬化的进展,而脾动脉缩窄术则保留了脾脏的功能.
목적 탐토비동맥축착대대서간경화진정적영향.방법 장96지SD대서수궤분3조,대조조부행개복술；절비조개복행비장절제술；비동맥축착조개복행비동맥축착술,연후복강주사류대을선알유도간경화모형.정기처사일정수량적대서,동태관찰대서혈상규、간공능、간조직병리개변급혈청Tuftsin수평변화.결과 술후대조조대서백세포、홍세포화혈소판축점하강(P＜0.05),이절비조화비동맥축착조미견명현변화(P＞0.05)；절비조여비동맥축착조적간공능손상화간경화정도교동기대조조상비경(P＜0.05)；비동맥축착조혈청Tuftsin수평여대조조비교차이무통계학의의(P＞0.05),이절비조Tuftsin수평현저하강(P＜0.05).결론 비동맥축착술화절비술균능유효지방지비공능항진적발생,종이연완간경화적진전,이비동맥축착술칙보류료비장적공능.
Objective To study the effect of splenic artery coarctation on liver cirrhosis process in rats and explore the value of splenic artery coarctation.Methods In this study,96 SD rats were randomized into 3 groups:control group,splenectomy group and splenic artery coaretation group.Liver cirrhosis was induced with intraperitoneal injection of thioacetamide.WBC,RBC,PLT,ALT,Alb,T-Bil,hepatic tissue pathology were evaluated among all groups in different phase.Results WBC,RBC,PLT of rats in control group,gradually decreased after surgery (P ＜ 0.05),while that in splenectomy group and splenic artery coarctation group did not change significantly (P ＞ 0.05).Liver function and the severity of liver cirrhosis in splenectomy group and splenic artery coarctation group were less compromised(P ＜ 0.05).Tuftsin level remained about the same in control group and splenic artery coarctation group (P ＞ 0.05),while decreased significandy in rats of splenectomy group (P ＜ 0.05).Conclusions Splenic artery coarctation and splenectomy can prevent hypersplenism and alleviate liver cirrhosis,at the same time splenic artery coarctation reserves the immune function of the spleen.