CAJ | 학술논문

目的探讨东北地区遗传性非息肉病性结直肠癌(HNPCC)家系多原发癌的特点.方法对登记的85个严格符合Amsterdam标准Ⅱ的HNPCC家系共509例患者的多原发癌的特点进行回顾性分析.结果在85个HNPCC家系中,共25个家系55例患者发生多原发癌,其中17个家系45例患者发生异时性多原发癌,12个家系16例患者发生同时性多原发癌,4个家系6例患者合并异时性和同时性多原发癌.结论中国东北地区HNPCC家系中多原发癌患者明显增多,最常见的为右半结肠癌、直肠癌、乙状结肠癌、横结肠癌、左半结肠癌、子宫内膜癌等.
목적 탐토동북지구유전성비식육병성결직장암(HNPCC)가계다원발암적특점.방법 대등기적85개엄격부합Amsterdam표준Ⅱ적HNPCC가계공509례환자적다원발암적특점진행회고성분석.결과 재85개HNPCC가계중,공25개가계55례환자발생다원발암,기중17개가계45례환자발생이시성다원발암,12개가계16례환자발생동시성다원발암,4개가계6례환자합병이시성화동시성다원발암.결론 중국동북지구HNPCC가계중다원발암환자명현증다,최상견적위우반결장암、직장암、을상결장암、횡결장암、좌반결장암、자궁내막암등.
Objective To investigate the familial incidence of multiple primary carcinoma in Chinese hereditary nonpolyposis colorectal cancer patients (HNPCC) in Northeast China.Methods By family line investigation,multiple primary carcinoma (MPC) spectrum' s characteristics of 509 patients in 85 families registered in strict conformity with the HNPCC Amsterdam criteria Ⅱ were analyzed retrospectively.Results Of the 85 HNPCC families,multiple primary carcinoma developed in 55 patients in 25 families,among them 45 patients had metachronous carcinoma in 17 families,16 patients had synchronous carcinoma occurred in 12 families,6 patients with both synchronous carcinoma and metachronous carcinoma in 4 families.Conclusions Multiple primary carcinoma developed in significantly high incidence in Northeast China in Chinese hereditary nonpolyposis colorectal cancer patients,the most common MPC are colorectal cancer and endometrial cancer.