中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2013年
5期
374-377
,共4页
吕顺增%赵婧%邹知耕%田铧%李菲%房云海%索宁%杨春林%刘书涛
呂順增%趙婧%鄒知耕%田鏵%李菲%房雲海%索寧%楊春林%劉書濤
려순증%조청%추지경%전화%리비%방운해%색저%양춘림%류서도
甲状腺肿瘤%受体,CCR7%钙黏着糖蛋白类%基质金属蛋白酶9%上皮间质转化
甲狀腺腫瘤%受體,CCR7%鈣黏著糖蛋白類%基質金屬蛋白酶9%上皮間質轉化
갑상선종류%수체,CCR7%개점착당단백류%기질금속단백매9%상피간질전화
Thyroid neoplasms%Receptors,CCR7%Cadherins%Matrix metalloproteinase 9%Epithelial mesenchymal transition
目的 研究并探讨趋化因子受体-7(chemokine receptor 7,CCR7)在结节性甲状腺肿与甲状腺乳头状癌中与上皮间质转化(epithelial mesenchymal transition,EMT)的关系.方法 采用免疫组化检测CCR7、N-cadherin与基质金属蛋白酶-9(matrix metalloproteinase 9,MMP9)在50例结节性甲状腺肿与50例甲状腺乳头状癌中的表达,分析其与患者病理资料的关系.结果 CCR7、N-cadherin在结节性甲状腺肿的结节期滤泡上皮均呈高表达(分别为83.7％、90.7％),且为正相关(P＜0.01),而在胶质贮存期滤泡上皮(分别为2.0％,8.2％)与结节期纤维组织(分别为6.7％,31.1％)低表达.CCR7、N-cadherin与MMP9在甲状腺乳头状癌的淋巴结转移组的阳性表达率为87.1％,90.3％,96.8％,而无淋巴结转移组的阳性表达率为42.1％,57.9％,63.2％,差异有统计学意义(P ＜0.01)；CCR7与N-cadherin、MMP9在甲状腺乳头状癌的表达呈正相关(P＜0.01).结论 CCR7在结节性甲状腺肿与甲状腺乳头状癌中均与EMT的指标具有相关性,CCR7可能参与调节滤泡上皮EMT发生.
目的 研究併探討趨化因子受體-7(chemokine receptor 7,CCR7)在結節性甲狀腺腫與甲狀腺乳頭狀癌中與上皮間質轉化(epithelial mesenchymal transition,EMT)的關繫.方法 採用免疫組化檢測CCR7、N-cadherin與基質金屬蛋白酶-9(matrix metalloproteinase 9,MMP9)在50例結節性甲狀腺腫與50例甲狀腺乳頭狀癌中的錶達,分析其與患者病理資料的關繫.結果 CCR7、N-cadherin在結節性甲狀腺腫的結節期濾泡上皮均呈高錶達(分彆為83.7％、90.7％),且為正相關(P＜0.01),而在膠質貯存期濾泡上皮(分彆為2.0％,8.2％)與結節期纖維組織(分彆為6.7％,31.1％)低錶達.CCR7、N-cadherin與MMP9在甲狀腺乳頭狀癌的淋巴結轉移組的暘性錶達率為87.1％,90.3％,96.8％,而無淋巴結轉移組的暘性錶達率為42.1％,57.9％,63.2％,差異有統計學意義(P ＜0.01)；CCR7與N-cadherin、MMP9在甲狀腺乳頭狀癌的錶達呈正相關(P＜0.01).結論 CCR7在結節性甲狀腺腫與甲狀腺乳頭狀癌中均與EMT的指標具有相關性,CCR7可能參與調節濾泡上皮EMT髮生.
목적 연구병탐토추화인자수체-7(chemokine receptor 7,CCR7)재결절성갑상선종여갑상선유두상암중여상피간질전화(epithelial mesenchymal transition,EMT)적관계.방법 채용면역조화검측CCR7、N-cadherin여기질금속단백매-9(matrix metalloproteinase 9,MMP9)재50례결절성갑상선종여50례갑상선유두상암중적표체,분석기여환자병리자료적관계.결과 CCR7、N-cadherin재결절성갑상선종적결절기려포상피균정고표체(분별위83.7％、90.7％),차위정상관(P＜0.01),이재효질저존기려포상피(분별위2.0％,8.2％)여결절기섬유조직(분별위6.7％,31.1％)저표체.CCR7、N-cadherin여MMP9재갑상선유두상암적림파결전이조적양성표체솔위87.1％,90.3％,96.8％,이무림파결전이조적양성표체솔위42.1％,57.9％,63.2％,차이유통계학의의(P ＜0.01)；CCR7여N-cadherin、MMP9재갑상선유두상암적표체정정상관(P＜0.01).결론 CCR7재결절성갑상선종여갑상선유두상암중균여EMT적지표구유상관성,CCR7가능삼여조절려포상피EMT발생.
Objective To explore the relationship of chemokine receptor 7 (CCR7) and epithelial mesenchymal transition (EMT) in thyroid goiter and thyroid papillary carcinoma.Methods CCR7,N-cadherin and MMP9 were detected by immunohistochemical technique in 50 cases of thyroid goiter tissues and 50 cases of thyroid papillary carcinoma tissues.The correlation between clinical pathological data and CCR7 expression were retrospectively analyzed.Results CCR7 and N-cadherin mainly located in nodular follicular epithelium (83.7％,90.7％) in thyroid goiter and correlated with each other statistically(P ＜0.01),the expression of CCR7 and N-cadherin were low in the follicular epithelium of storage period (2.0％,8.2％) and the nodular fibrous tissues (6.7％,31.1％) of thyroid goiter.The expression rate of CCR7,N-cadherin and MMP9 in thyroid papillary carcinoma tissues with lymph node metastasis was 87.1％,90.3％,96.8％ respectively,while the expression rate of CCR7,N-cadherin and MMP9 in thyroid papillary carcinoma tissues without lymph node metastasis was 42.1％,57.9％,63.2％ respectively.CCR7,MMP9 and N-cadherin were significantly correlated with lymph node metastasis (P ＜ 0.01).CCR7 was positively correlated with N-cadherin,MMP9 (P ＜ 0.01).Conclusions CCR7 is associated with EMT indicators (MMP9 and N-cadherin) in thyroid goiter and thyroid papillary carcinoma.CCR7 might play a role in the genesis of EMT in the follicle epithelium.
