CAJ | 학술논문

目的系统评价预防性应用抗生素对腹股沟无张力疝修补术后切口感染的作用.方法检索1975年12月至2012年10月公开发表的所有预防性使用抗菌药物对腹股沟无张力疝修术切口感染影响的随机对照试验,进行荟萃分析及系统评价.结果筛选符合纳入标准的随机对照试验11项,共4159例患者；共有130例发生切口感染,感染率为3.13％.其中预防性应用抗生素组1845例,有例45发生切口感染,感染率为1.94％；对照组2314例,有85例发生切口感染,感染率为3.67％.与对照组相比,预防性使用抗菌药物组可以减少手术部位感染(OR0.55,95％ CI0.38～0.80,P=0.002).结论行腹股沟疝无张力修补术的患者,术前预防性使用抗生素能有效降低切口感染率.
목적 계통평개예방성응용항생소대복고구무장력산수보술후절구감염적작용.방법 검색1975년12월지2012년10월공개발표적소유예방성사용항균약물대복고구무장력산수술절구감염영향적수궤대조시험,진행회췌분석급계통평개.결과 사선부합납입표준적수궤대조시험11항,공4159례환자；공유130례발생절구감염,감염솔위3.13％.기중예방성응용항생소조1845례,유례45발생절구감염,감염솔위1.94％；대조조2314례,유85례발생절구감염,감염솔위3.67％.여대조조상비,예방성사용항균약물조가이감소수술부위감염(OR0.55,95％ CI0.38～0.80,P=0.002).결론 행복고구산무장력수보술적환자,술전예방성사용항생소능유효강저절구감염솔.
Objective We conducted a systematic review and meta-analysis of the published literature to evaluate the efficacy of prophylactic antibiotics in the prevention of incisional infection of inguinal tension-free hernioplasty.Methods Articles of randomized controlled trials about the efficacy of prophylactic antibiotics in the prevention of incisional infection in the inguinal tension-free hernioplasty published from January 1975 to October 2012 was retrieved and systematically reviewed.Results A total of 11 randomized controlled trials meeting the inclusion criteria were screened.Among the 4159 cases of patients,130 cases had wound infection,and the infection rate was 3.13％.In the prophylactic antibiotics group of 1845 cases,wound infection occurred in 45 cases; the infection rate was 1.94％.In the control group of 2314 cases,85 cases had incision infection; the infection rate was 3.67％.The preventive use of antimicrobial drugs reduced surgical site infection of inguinal tension-free hernioplasty (OR 0.55,95％ CI 0.38-0.80,P =0.002).Conclusions The use of prophylactic antibiotics can effectively reduce the incisional infection in the inguinal tension-free hernioplasty.