CAJ | 학술논문

目的探讨乙肝病毒(HBV)感染对肝内胆管细胞癌(intrahepatic cholangiocarcinoma,tCC)患者术后生存的影响.方法收集60例ICC患者的临床病理资料,按血清中乙肝病毒五项指标分为三组,A组为乙肝表面抗原或核心抗体阳性患者26例,B组为乙肝表面抗体单独阳性患者17例,C组为乙肝五项指标全部阴性患者17例,采用Kaplan-Meier法进行三组总生存率的比较,用Cox模型进行多因素分析. 结果三组患者l、3年总生存率分别为:50％、53％、29％;22％、18％、0;中位生存时间分别为12个月、12个月、6个月,差异有统计学意义(X2 =6.48,P=0.039).多因素分析发现:术前血清总胆红素水平、肿块位置、乙肝病毒感染或注射乙肝疫苗、肝内胆管结石以及术后辅助化疗是生存的独立影响因子.结论术前HBV感染或注射乙肝疫苗的ICC患者生存期更长,且为独立的预后因素.
목적 탐토을간병독(HBV)감염대간내담관세포암(intrahepatic cholangiocarcinoma,tCC)환자술후생존적영향.방법 수집60례ICC환자적림상병리자료,안혈청중을간병독오항지표분위삼조,A조위을간표면항원혹핵심항체양성환자26례,B조위을간표면항체단독양성환자17례,C조위을간오항지표전부음성환자17례,채용Kaplan-Meier법진행삼조총생존솔적비교,용Cox모형진행다인소분석. 결과 삼조환자l、3년총생존솔분별위:50％、53％、29％;22％、18％、0;중위생존시간분별위12개월、12개월、6개월,차이유통계학의의(X2 =6.48,P=0.039).다인소분석발현:술전혈청총담홍소수평、종괴위치、을간병독감염혹주사을간역묘、간내담관결석이급술후보조화료시생존적독립영향인자.결론 술전HBV감염혹주사을간역묘적ICC환자생존기경장,차위독립적예후인소.
Objective To evaluate the impact of chronic hepatitis B virus (HBV) infection on the outcome following resection for intrahepatic cholangiocarcinoma (ICC) patients.Methods The clinicpathological data of 60 consecutive operated ICC patients were collected.These patients were divided into group A with HBV infection,represented by serum positive hepatitis B surface antigen (HBsAg),group B with hepatitis B surface antibody (HBsAb) positive,and group C with all serum marker of HBV negative.The overall survival rate was evaluated.Results The 1-and 3-year overall survival rate and median survival of three groups were 50％ vs 53％ vs 29％ ; 22％ vs 18％ vs O; and 12.0 m vs 12.0 m vs 6 m,respectively.The difference was statistically significant(P =0.037).Multivariate analyses revealed that the preoperative serum level of TIBL,tumor location,HBV infection or injection of hepatitis B vaccine,hepatolithiasis and adjuvant chemotherapy were related to the prognosis.Conclusions HBV infection or injection of hepatitis B vaccine is favorable independent factor for prognosis of patients with intrahepatic cholangiocarcinoma after resection.