CAJ | 학술논문

目的研究腹腔镜胃癌手术和开腹胃癌手术对肠道屏障功能影响的差异.方法 2008年5月至2012年5月在宁波鄞州第二医院普外科行腹腔镜胃癌手术32例,开腹胃癌手术32例,分别抽取两组患者的术前1d、术后第1、3、7天的外周静脉血,采用分光光度法检测血浆中D-乳酸和二胺氧化酶(diamine oxidase,DAO)的浓度. 结果两组患者在手术时间、术中出血量及术后开始进食天数上相比差异均有统计学意义,均P＜0.05.两组患者术前1d及术后第1、3、7天血浆D-乳酸水平相比差异均无统计学意义(均P＞0.05).两组在上述各时间点血浆DAO水平相比差异均无统计学意义(均P ＞0.05).结论腹腔镜胃癌根治术对肠道屏障功能的损伤与开腹胃癌根治术相比无差异.
목적 연구복강경위암수술화개복위암수술대장도병장공능영향적차이.방법 2008년5월지2012년5월재저파은주제이의원보외과행복강경위암수술32례,개복위암수술32례,분별추취량조환자적술전1d、술후제1、3、7천적외주정맥혈,채용분광광도법검측혈장중D-유산화이알양화매(diamine oxidase,DAO)적농도. 결과 량조환자재수술시간、술중출혈량급술후개시진식천수상상비차이균유통계학의의,균P＜0.05.량조환자술전1d급술후제1、3、7천혈장D-유산수평상비차이균무통계학의의(균P＞0.05).량조재상술각시간점혈장DAO수평상비차이균무통계학의의(균P ＞0.05).결론 복강경위암근치술대장도병장공능적손상여개복위암근치술상비무차이.
Objective To study the influence of laparoscopic gastric surgery on the gut barrier function (GBF).Methods There were 64 gastric cancer patients undergoing respectively laparoscopic radical procedures (32 cases) and open gastric surgery (32 cases).Blood was drawn on day one before surgery,day 1,day 3 and day 7 after the surgery for the measurement of plasma D-lacate and plasma diamine oxidase activity by using ultraviolet spectrophotometry.Results There was no statistical difference among demographic,clinicopathological characterastics between the two groups (P ＞ 0.05).The difference on the operative time,blood loss and the time starting to take food after the surgery was significant between the two groups,P ＜ 0.05.The differences of plasma D-lacate level and the diamine oxidase (DAO) on perioperatively respective all time points were not significant between the two groups,P ＞ 0.05.Conclusion Laparoscopic radical gastrectomy is comparable to open procedures in causing damage to patient's gut barrier functions.