CAJ | 학술논문

目的探讨异基因造血干细胞移植后人巨细胞病毒(CMV)感染与移植物抗宿主病(GVHD)的关系.方法对1998年3月至2001年3月进行的63例造血干细胞移植受者的CMV感染情况进行检测,用聚合酶链反应法检测CMV gB分型,并统计受者GVHD的发生情况.结果 40例发生CMV感染,23例未感染,其GVHD发生率分别为82.5％(33/40)和47.8％(11/23),差异有统计学意义(P＜0.01).CMV gB-1、gB-2、gB-3型感染者发生Ⅱ～Ⅳ度急性GVHD的几率分别为58.8％(10/17)、40％(2/5)和66.7％(4/6),三者间差异无统计学意义(P＞0.05).CMV阳性受者中27.5％(11/40)出现移植后继发性造血抑制,CMV阴性的受者13.0％ (3/23)出现,发生率的差异无统计学意义(P＞0.05).结论 CMV感染者GVHD的发生率升高,而CMV感染与GVHD严重程度无关,合理治疗后不会显著抑制移植后的造血重建.
목적 탐토이기인조혈간세포이식후인거세포병독(CMV)감염여이식물항숙주병(GVHD)적관계.방법 대1998년3월지2001년3월진행적63례조혈간세포이식수자적CMV감염정황진행검측,용취합매련반응법검측CMV gB분형,병통계수자GVHD적발생정황.결과 40례발생CMV감염,23례미감염,기GVHD발생솔분별위82.5％(33/40)화47.8％(11/23),차이유통계학의의(P＜0.01).CMV gB-1、gB-2、gB-3형감염자발생Ⅱ～Ⅳ도급성GVHD적궤솔분별위58.8％(10/17)、40％(2/5)화66.7％(4/6),삼자간차이무통계학의의(P＞0.05).CMV양성수자중27.5％(11/40)출현이식후계발성조혈억제,CMV음성적수자13.0％ (3/23)출현,발생솔적차이무통계학의의(P＞0.05).결론 CMV감염자GVHD적발생솔승고,이CMV감염여GVHD엄중정도무관,합리치료후불회현저억제이식후적조혈중건.
Objective To investigate the correlation between cytomegalovirus (CMV) infection and graft-versus-host disease (GVHD) occurrence after allogeneic hematopoietic stem-cell transplantation (HSCT).Methods Sixty-three patients received allogeneic HSCT from Mar.1998 to Mar.2001.CMV infection and classification were tested by using polymerase chain reaction (PCR) after transplantation.The GVHD occurrence was statistically analyzed.Results 82.5％ (33/40) and 47.8％ (11/23) of patients manifested GVHD in CMV-infected and CMV-uninfected ones,which showed significant difference (P＜0.01).58.8％ (10/17),40％ (2/5),and 66.7％ (4/6) of patients manifested grade Ⅲ-Ⅳ GVHD in gB-1,gB-2,and gB-3-infected ones,respectively,which showed no significant difference (P＞ 0.05).The inhibition of haematopoietic reconstitution was observed in 27.5％ (11/40) of CMV-infected patients,which was about twice higher than in CMV-uninfected patients (13％,3/23).Conclusion CMV infection increases the risk of GVHD,but does not significantly inhibit haematopoietic reconstitution after transplantation.