CAJ | 학술논문

目的探讨肾移植术后妊娠对受者及移植肾的影响.方法回顾性分析5例6次肾移植术后妊娠的临床资料.结果受者妊娠时平均年龄为31.1岁,移植至妊娠的时间平均为3.6年.5例6次妊娠中发生先兆子痫2例次,高脂血症1例次.最终成功分娩4例,分别于38周、35周、35周和38周接受剖宫产,新生儿平均体重为3262.5 g,新生儿Apgar评分均为10分.2例次因减少或停用免疫抑制剂,移植肾功能丧失而终止妊娠,其中1例接受再次肾移植后再次妊娠并成功分娩.结论对于移植肾功能正常的女性受者,在合理应用免疫抑制剂的前提下妊娠和分娩是可行的,但具有较高风险,需要严密监护.
목적 탐토신이식술후임신대수자급이식신적영향.방법 회고성분석5례6차신이식술후임신적림상자료.결과 수자임신시평균년령위31.1세,이식지임신적시간평균위3.6년.5례6차임신중발생선조자간2례차,고지혈증1례차.최종성공분면4례,분별우38주、35주、35주화38주접수부궁산,신생인평균체중위3262.5 g,신생인Apgar평분균위10분.2례차인감소혹정용면역억제제,이식신공능상실이종지임신,기중1례접수재차신이식후재차임신병성공분면.결론 대우이식신공능정상적녀성수자,재합리응용면역억제제적전제하임신화분면시가행적,단구유교고풍험,수요엄밀감호.
Objective To evaluate the effect of pregnancy and delivery after renal transplantation (RT)on recipients,graft and offspring.Methods Clinical data of 6 pregnancies in 5 recipients were retrospectively studied and literature was reviewed.Results Among them,6 pregnancies and 4 deliveries occurred in 5 female RT recipients.The mean age at pregnancy was 31.1 years,with a mean interval between RT and pregnancy being 3.6 years.Preeclampsia developed in two pregnancies and hyperlipemia in one pregnancy.One RT recipient who discontinued immunosuppressant following pregnancy on her own exhibited subsequent renal failure.She underwent a second RT and delivered a healthy baby two years following the second RT.One RT recipient decreased the immunosuppressant dose to half after the pregnancy on her own and developed renal failure thereafter.Four patients underwent a Cesarean section at 38 th,35 th,35 th,and 38 th week,respectively.The mean birth weight was 3262.5 g with all Apgar scores of 10.Conclusion Our data coupled with prior reports suggest that for the recipients with normal renal function,successful pregnancy is achievable if immunosuppressant was taken correctly,but the pregnancy is at high risk,and careful monitoring is needed.