国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
16期
2425-2427
,共3页
黄丽芬%邓子德%叶晓新%陈志敏%贾卫东%陈伟烈%曾燕
黃麗芬%鄧子德%葉曉新%陳誌敏%賈衛東%陳偉烈%曾燕
황려분%산자덕%협효신%진지민%가위동%진위렬%증연
HIV/AIDS%死亡%危险因素%医院感染%机会性感染
HIV/AIDS%死亡%危險因素%醫院感染%機會性感染
HIV/AIDS%사망%위험인소%의원감염%궤회성감염
HIV/AIDS%Death%Risk factor%Nosocomial infection%Opportunistic infection
目的 探讨某院408例HIV/AIDS死亡病例医院感染、机会性感染的特征.方法 对408例HIV/AIDS住院死亡病例进行回顾性分析.结果 某医院HIV/AIDS住院患者4434例,死亡408例,住院病死率9.20％.实行免费抗病毒治疗以来,病死率较前下降.医院感染49例(12.01％),54例次(13.24％).病原体最常见的是细菌13例次(24.07％).常见部位是呼吸、消化系统,分别是20例次(37.04％)、12例次(22.22％).本组病例医院感染的危险因素分别是合并两个及以上部位的其他机会性感染、住院时间大于30 d、侵袭性操作、使用二联以上抗菌药物、CD4+T淋巴细胞计数小于200个/μl.98.77％的死亡病例中出现机会性感染1041例次,与死亡直接相关的占81.13％.病原体最常见是真菌393例次(37.75％),感染部位以肺部、口腔为主,分别是335例次(32.18％)、231例次(22.19％),其中艾滋病指征性机会性感染334例次(32.08％).结论 机会性感染(包括医院感染)是HIV/AIDS主要的死亡原因.早期诊断和积极控制机会性感染,防止医院感染,及时有效的HAART治疗是提高HIV/AIDS患者生存质量的关键.
目的 探討某院408例HIV/AIDS死亡病例醫院感染、機會性感染的特徵.方法 對408例HIV/AIDS住院死亡病例進行迴顧性分析.結果 某醫院HIV/AIDS住院患者4434例,死亡408例,住院病死率9.20％.實行免費抗病毒治療以來,病死率較前下降.醫院感染49例(12.01％),54例次(13.24％).病原體最常見的是細菌13例次(24.07％).常見部位是呼吸、消化繫統,分彆是20例次(37.04％)、12例次(22.22％).本組病例醫院感染的危險因素分彆是閤併兩箇及以上部位的其他機會性感染、住院時間大于30 d、侵襲性操作、使用二聯以上抗菌藥物、CD4+T淋巴細胞計數小于200箇/μl.98.77％的死亡病例中齣現機會性感染1041例次,與死亡直接相關的佔81.13％.病原體最常見是真菌393例次(37.75％),感染部位以肺部、口腔為主,分彆是335例次(32.18％)、231例次(22.19％),其中艾滋病指徵性機會性感染334例次(32.08％).結論 機會性感染(包括醫院感染)是HIV/AIDS主要的死亡原因.早期診斷和積極控製機會性感染,防止醫院感染,及時有效的HAART治療是提高HIV/AIDS患者生存質量的關鍵.
목적 탐토모원408례HIV/AIDS사망병례의원감염、궤회성감염적특정.방법 대408례HIV/AIDS주원사망병례진행회고성분석.결과 모의원HIV/AIDS주원환자4434례,사망408례,주원병사솔9.20％.실행면비항병독치료이래,병사솔교전하강.의원감염49례(12.01％),54례차(13.24％).병원체최상견적시세균13례차(24.07％).상견부위시호흡、소화계통,분별시20례차(37.04％)、12례차(22.22％).본조병례의원감염적위험인소분별시합병량개급이상부위적기타궤회성감염、주원시간대우30 d、침습성조작、사용이련이상항균약물、CD4+T림파세포계수소우200개/μl.98.77％적사망병례중출현궤회성감염1041례차,여사망직접상관적점81.13％.병원체최상견시진균393례차(37.75％),감염부위이폐부、구강위주,분별시335례차(32.18％)、231례차(22.19％),기중애자병지정성궤회성감염334례차(32.08％).결론 궤회성감염(포괄의원감염)시HIV/AIDS주요적사망원인.조기진단화적겁공제궤회성감염,방지의원감염,급시유효적HAART치료시제고HIV/AIDS환자생존질량적관건.
Objective To analyze the characteristics of nosocomial infections (NI) and opportunistic infections (OI) of death cases in HIV/AIDS patients in a hospital.Method A retrospective analysis on a group of 408 HIV/AIDS death cases from Jan 2001 to Dec 2012 was conducted.Results There were 4,434 hospitalized cases with HIV/AIDS in a hospital in total and 408 cases died,the fatality rate was 9.20％.Since the introduction of free anti-viral treatment,the fatality rate of HIV/AIDS declined.49 cases of NI were found among 408 death cases,and the NI rate was 12.01％.Bacteria were the most common pathogens in NI.The most frequent infection sites were respiratory system and digestive system.The risk factors for NI were opportunistic infection of at least two sites,hospital stay over 30 days,invasive operations,CD4+T lymphocyte count lower than 200 cells/μ l and combination antibiotics administration.There were 1041 cases of OI totally.81.13％ of OI was related to death directly.Fungal infection was the most common in OI.Most of the OI occurred in lung,mouth.The AIDS defining opportunistic infections accounted for 32.08％.Conclusions Opportunistic infections involving nosocomial infections are the most important cause of death.Early diagnosis and treatment for opportunistic infections,preventing and controlling nosocomial infection is the key to improve the life quality of HIV/AIDS patients.
