中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2013年
6期
353-357
,共5页
翁国斌%张曙伟%李毛毛%姚许平%祁洪刚%任雨%楼冠仲
翁國斌%張曙偉%李毛毛%姚許平%祁洪剛%任雨%樓冠仲
옹국빈%장서위%리모모%요허평%기홍강%임우%루관중
糖尿病%肾移植%基因%多态性,单核苷酸
糖尿病%腎移植%基因%多態性,單覈苷痠
당뇨병%신이식%기인%다태성,단핵감산
Diabetes mellitus%Kidney transcription%Genes%Polymorphism%single nucleotide
目的 探讨浙东地区汉族人群TCF7L2基因与肾移植后糖尿病(PTDM)的相关性.方法 应用基因直接测序方法检测糖尿病组(普通糖尿病患者,90例)、非PTDM组(肾移植后未发生PTDM的受者,112例)和PTDM组(肾移植后发生PTDM的受者,68例)的TCF7L2基因多态位点rs7903146和rs290487的基因分型,比较各位点的等位基因和基因型的分布频率,分析其与PTDM的相关性.结果 PTDM组中5.1％的rs7903146基因多态位点为T等位基因,非PTDM组中为1.3％(P＜0.05).PTDM组中,携带rs7903146位点CT/TT基因型者占70.0％,携带CC基因型者占35.8％(P＜0.05).PTDM组携带rs290487基因CC、CT和TT基因型者分别占14.7％、38.2％和47.1％(P＞0.05).TCF7L2基因多态位点rs7403146的CT基因型携带者罹患PTDM的风险有所增加(比值比=18.54,95％可信区间=1.21～282.26,P=0.03).结论 TCF7L2基因多态位点rs7903146的CT基因型与肾PTDM的发生具有显著相关性.
目的 探討浙東地區漢族人群TCF7L2基因與腎移植後糖尿病(PTDM)的相關性.方法 應用基因直接測序方法檢測糖尿病組(普通糖尿病患者,90例)、非PTDM組(腎移植後未髮生PTDM的受者,112例)和PTDM組(腎移植後髮生PTDM的受者,68例)的TCF7L2基因多態位點rs7903146和rs290487的基因分型,比較各位點的等位基因和基因型的分佈頻率,分析其與PTDM的相關性.結果 PTDM組中5.1％的rs7903146基因多態位點為T等位基因,非PTDM組中為1.3％(P＜0.05).PTDM組中,攜帶rs7903146位點CT/TT基因型者佔70.0％,攜帶CC基因型者佔35.8％(P＜0.05).PTDM組攜帶rs290487基因CC、CT和TT基因型者分彆佔14.7％、38.2％和47.1％(P＞0.05).TCF7L2基因多態位點rs7403146的CT基因型攜帶者罹患PTDM的風險有所增加(比值比=18.54,95％可信區間=1.21～282.26,P=0.03).結論 TCF7L2基因多態位點rs7903146的CT基因型與腎PTDM的髮生具有顯著相關性.
목적 탐토절동지구한족인군TCF7L2기인여신이식후당뇨병(PTDM)적상관성.방법 응용기인직접측서방법검측당뇨병조(보통당뇨병환자,90례)、비PTDM조(신이식후미발생PTDM적수자,112례)화PTDM조(신이식후발생PTDM적수자,68례)적TCF7L2기인다태위점rs7903146화rs290487적기인분형,비교각위점적등위기인화기인형적분포빈솔,분석기여PTDM적상관성.결과 PTDM조중5.1％적rs7903146기인다태위점위T등위기인,비PTDM조중위1.3％(P＜0.05).PTDM조중,휴대rs7903146위점CT/TT기인형자점70.0％,휴대CC기인형자점35.8％(P＜0.05).PTDM조휴대rs290487기인CC、CT화TT기인형자분별점14.7％、38.2％화47.1％(P＞0.05).TCF7L2기인다태위점rs7403146적CT기인형휴대자리환PTDM적풍험유소증가(비치비=18.54,95％가신구간=1.21～282.26,P=0.03).결론 TCF7L2기인다태위점rs7903146적CT기인형여신PTDM적발생구유현저상관성.
Objective To study the relationship between rs290487,rs7903146 of transcription factor 7-Like 2 (TCF7L2) gene and post-transplantation diabetes mellitus in Han Zhejiang population.Method We genotyped two single nucleotide polymorphisms (SNPs) across the TCF7L2 gene in 90 unrelated post-transplantation type 2 diabetes mellitus (PTDM) patients,112 unrelated non-PTDM patients,and a set of post-transplantation diabetes mellitus patients (n =68).Genotyping was performed using direct sequencing SNP Genotyping Assays.The association of SNPs with post-transplantation diabetes mellitus was analyzed.Result In this study,there was statistically significant difference in the T-allele of TCF7L2.rs7903146 between PTDM group (5.1％) and non-PTDM group (1.3％) (P＜0.05).For rs7903146,the frequencies of genotype C/C,C/T (70.0％) and T/T (35.8％) was statistically significant in PTDM group (P＜0.05).For rs290487,the frequencies of genotype C/C,C/T and T/T was 14.7％,38.2％ and 47.1％ respectively in PTDM group,P＞ 0.05.The incidence of PTDM was significantly higher in patients with the CT genotype (odds ratio 18.54 [95％ CI 1.21-282.26],P =0.03).Conclusion With the current sample size,we found that the CT genotype of rs7903146 was significantly associated with post-transplantation diabetes mellitus.
