CAJ | 학술논문

目的探讨异基因造血干细胞移植(allo-HSCT)后胃肠道移植物抗宿主病(GVHD)发生的危险因素.方法选择2003-2012年接受allo-HSCT的214例受者,对受者胃肠道GVHD程度进行评估,分析受者原发疾病、性别、年龄、预处理强度、供者类型、CD34+细胞数及预处理方案中是否应用抗淋巴细胞球蛋白(ALG)等因素对胃肠道GVHD发生的影响,评估不同程度胃肠道GVHD对免疫治疗的反应,评价伴有不同程度胃肠道GVHD受者的预后.结果经过单因素与多因素分析,供者类型和预处理强度与胃肠道GVHD的发生之间存在明显的相关性(P＜0.05);对亲缘HLA全相合allo-HSCT受者,使用减低剂量的预处理方案者的胃肠道GVHD发生率较标准强度或加强剂量的预处理方案者低(P＜0.05).结论供者类型和预处理强度可能是导致胃肠道GVHD发生的主要危险因素.
목적 탐토이기인조혈간세포이식(allo-HSCT)후위장도이식물항숙주병(GVHD)발생적위험인소.방법 선택2003-2012년접수allo-HSCT적214례수자,대수자위장도GVHD정도진행평고,분석수자원발질병、성별、년령、예처리강도、공자류형、CD34+세포수급예처리방안중시부응용항림파세포구단백(ALG)등인소대위장도GVHD발생적영향,평고불동정도위장도GVHD대면역치료적반응,평개반유불동정도위장도GVHD수자적예후.결과 경과단인소여다인소분석,공자류형화예처리강도여위장도GVHD적발생지간존재명현적상관성(P＜0.05);대친연HLA전상합allo-HSCT수자,사용감저제량적예처리방안자적위장도GVHD발생솔교표준강도혹가강제량적예처리방안자저(P＜0.05).결론 공자류형화예처리강도가능시도치위장도GVHD발생적주요위험인소.
Objective To investigate the risk factors of gastrointestinal graft versus host disease(GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Method 214 patients receiving allo-HSCT from 2003 to 2012 were enrolled in this study,and assessed on the degree of gastrointestinal GVHD.The effects of the primary diseases status,gender,age,conditioning regimen intensity,donor type,the number of cells positive for the CD34 expression,and the use of anti-lymphocyte immunoglobulin (ALG) in the pretreatment scheme on the occurrence of gastrointestinal GVHD was studied.The responses of different degrees of GVHD to immunotherapy were evaluated.Result Univariate and multivariate analyses revealed that the graft type and the conditioning regimen intensity were the risk factors of gastrointestinal GVHD (P＜0.05).Conclusion Donor type and conditioningregimen intensity may be the main risk factors of gastrointestinal GVHD.