中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2014年
5期
273-276
,共4页
袁小鹏%周健%陈传宝%韩明%王小平%焦兴元%王长希%何晓顺
袁小鵬%週健%陳傳寶%韓明%王小平%焦興元%王長希%何曉順
원소붕%주건%진전보%한명%왕소평%초흥원%왕장희%하효순
肾移植%器官保存%器官保存液%移植肾功能恢复延迟
腎移植%器官保存%器官保存液%移植腎功能恢複延遲
신이식%기관보존%기관보존액%이식신공능회복연지
Kidney transplantation%Organ preservation%Organ preservation solutions%Delayed graft function
目的 探讨机器低温脉冲灌注保存供肾在心脏死亡器官捐赠(DCD)肾移植中的应用.方法 40例DCD供者,采用机器灌注保存一侧供肾(机器灌注组),另一侧常规静态低温保存供肾(冷储存组).比较两组移植肾功能延迟恢复(DGF)发生率和移植肾功能水平.结果 8例供者因肾脏灌注阻力过高弃用供肾,肾脏灌注流量为(0.74±0.16) ml/s[(44.5±9.5)ml/min],灌注阻力为(4.64±1.20)kPa·s-1 ·ml-1 [(0.58±0.15)mmHg·ml-1 ·min-1].32例供者的肾脏用于移植,灌注流量为(1.54±0.55) ml/s[(92.4±32.9)ml/min],肾脏灌注阻力为(2.56±1.04) kPa· s-1 ·ml-1[(0.32±0.13)mmHg·min-1 ·ml-1].机器灌注组和冷储存组DGF发生率分别为15.6％和18.8％,差异无统计学意义(P＞0.05).两组术后1个月、6个月和12个月估算的肾小球滤过率的差异均无统计学意义.结论 采用机器灌注判断DCD供肾质量安全性良好,但是对于减少术后DGF和改善移植肾功能无明显作用.
目的 探討機器低溫脈遲灌註保存供腎在心髒死亡器官捐贈(DCD)腎移植中的應用.方法 40例DCD供者,採用機器灌註保存一側供腎(機器灌註組),另一側常規靜態低溫保存供腎(冷儲存組).比較兩組移植腎功能延遲恢複(DGF)髮生率和移植腎功能水平.結果 8例供者因腎髒灌註阻力過高棄用供腎,腎髒灌註流量為(0.74±0.16) ml/s[(44.5±9.5)ml/min],灌註阻力為(4.64±1.20)kPa·s-1 ·ml-1 [(0.58±0.15)mmHg·ml-1 ·min-1].32例供者的腎髒用于移植,灌註流量為(1.54±0.55) ml/s[(92.4±32.9)ml/min],腎髒灌註阻力為(2.56±1.04) kPa· s-1 ·ml-1[(0.32±0.13)mmHg·min-1 ·ml-1].機器灌註組和冷儲存組DGF髮生率分彆為15.6％和18.8％,差異無統計學意義(P＞0.05).兩組術後1箇月、6箇月和12箇月估算的腎小毬濾過率的差異均無統計學意義.結論 採用機器灌註判斷DCD供腎質量安全性良好,但是對于減少術後DGF和改善移植腎功能無明顯作用.
목적 탐토궤기저온맥충관주보존공신재심장사망기관연증(DCD)신이식중적응용.방법 40례DCD공자,채용궤기관주보존일측공신(궤기관주조),령일측상규정태저온보존공신(랭저존조).비교량조이식신공능연지회복(DGF)발생솔화이식신공능수평.결과 8례공자인신장관주조력과고기용공신,신장관주류량위(0.74±0.16) ml/s[(44.5±9.5)ml/min],관주조력위(4.64±1.20)kPa·s-1 ·ml-1 [(0.58±0.15)mmHg·ml-1 ·min-1].32례공자적신장용우이식,관주류량위(1.54±0.55) ml/s[(92.4±32.9)ml/min],신장관주조력위(2.56±1.04) kPa· s-1 ·ml-1[(0.32±0.13)mmHg·min-1 ·ml-1].궤기관주조화랭저존조DGF발생솔분별위15.6％화18.8％,차이무통계학의의(P＞0.05).량조술후1개월、6개월화12개월고산적신소구려과솔적차이균무통계학의의.결론 채용궤기관주판단DCD공신질량안전성량호,단시대우감소술후DGF화개선이식신공능무명현작용.
Objective To explore the effectiveness of machine hypothermic pulsatile perfusion preservation (PPP) for kidneys from donation after cardiac death (DCD) donors.Method One of the two kidneys from 40 DCD donors were pumped by LifePort Kidney Transporter (PPP group),and another kidney was preserved by static cold-storage preservation (cold-storage group).The incidence of delayed graft function (DGF) and renal graft function of two groups were analyzed.Result Sixteen kidneys from 8 donors were discarded,with flow of 44.5 ± 9.5 mL/min and resistances of 0.58 ± 0.15 mmHg/(mL/min).Sixty-four kidneys from 32 donors were transplanted,with flow of 92.4 ± 32.9mL/min and resistances of 0.32 ± 0.13 mmHg/(mL/min).PPP group and cold-storage group showed similar incidence of DGF (15.6％ vs.18.8 ％,P ＞ 0.05) and comparable estimated glomerular filtration rate at 1st,6th and 12th month after transplantation.Conclusion PPP is a useful method for viability testing for kidneys from DCD.But it seems that PPP can not decrease the incidence DGF or improve the renal graft function from DCD donors.
