CAJ | 학술논문

将51例蜂蜇伤患者分成轻(22例)、中(20例)、重(9例)度3组,将30名健康者作为正常对照组.检测血IL-8、血管性假血友病因子(vWF)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体水平.轻度组各项指标与正常对照组比较差异无统计学意义(P＞0.05).中重度中毒组PT、APTT、TT、IL-8、vWF的水平较轻度中毒组明显升高(P＜0.01),重度中毒组的APTT、IL-8、vWF水平又较中度中毒组明显升高(P＜0.01).
장51례봉철상환자분성경(22례)、중(20례)、중(9례)도3조,장30명건강자작위정상대조조.검측혈IL-8、혈관성가혈우병인자(vWF)、응혈매원시간(PT)、부분응혈활매시간(APTT)、응혈매시간(TT)、섬유단백원(FIB)화D-이취체수평.경도조각항지표여정상대조조비교차이무통계학의의(P＞0.05).중중도중독조PT、APTT、TT、IL-8、vWF적수평교경도중독조명현승고(P＜0.01),중도중독조적APTT、IL-8、vWF수평우교중도중독조명현승고(P＜0.01).
Fifty-one patients with bee-sting poisoning were divided into slight poisoning group (n =22),moderate poisoning group (n =20) and severe poisoning group (n =9).And 30 healthy persons were selected as control group.The levels of interleukin-8 (IL-8),Von Willebrand factor (vWF),prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB),thrombin time (TT) and D-dimer were measured.The levels of all parameters in slight poisoning group were no significantly different from with control group (P ＞ 0.05).The levels of PT,APTT,IL-8 and vWF were significantly higher in moderate and severe poisoning groups than those in the control group (P ＜0.01).But the levels of APTT,IL-8 and vWF in severe poisoning group were much higher than those in moderate poisoning group (P ＜0.01).The injury of vascular endothelial cell by IL-8 and vWF caused the change of coagulative function and promoted the progress of inflammation.