CAJ | 학술논문

以汉密尔顿抑郁量表(HAMD》＞17分和＜17分为标准,将120例慢性阻塞性肺疾病患者分为伴发抑郁组和不伴发抑郁组,根据简易精神状态法测定患者认知功能,并测定患者血氧饱和度及肺功能.120例患者中54例合并抑郁,HAMD评分与患者的血氧饱和度以及肺功能呈负相关(P＜0.05)；多因素回归分析显示,性别、血氧饱和度及精神状态总分与患者的抑郁情绪存在统计学差异(P＜0.05)；抑郁组精神状态分数较非抑郁组明显降低(P＜0.05),与血氧饱和度呈正相关(P＜0.01)；精神状态分数与HAMD评分呈负相关(r=-0.549,P＜0.01).
이한밀이돈억욱량표(HAMD》＞17분화＜17분위표준,장120례만성조새성폐질병환자분위반발억욱조화불반발억욱조,근거간역정신상태법측정환자인지공능,병측정환자혈양포화도급폐공능.120례환자중54례합병억욱,HAMD평분여환자적혈양포화도이급폐공능정부상관(P＜0.05)；다인소회귀분석현시,성별、혈양포화도급정신상태총분여환자적억욱정서존재통계학차이(P＜0.05)；억욱조정신상태분수교비억욱조명현강저(P＜0.05),여혈양포화도정정상관(P＜0.01)；정신상태분수여HAMD평분정부상관(r=-0.549,P＜0.01).
Based upon the measure of depression as defined by Hamilton depression scale (HAMD)scores ＞ 17,120 patients with chronic obstructive pulmonary disease (COPD) were classified into 2 groups:COPD patients with or without depression.According to the mini-mental state examination (MMSE),the cognitive functions of all patients were evaluated.Meanwhile,oxygen saturation and pulmonary function were measured by blood gas analyzer and spirometer respectively.Fifty-four COPD patients were complicated with depression.HAMD scores were significantly negatively correlated with oxygen saturation and pulmonary function (P ＜0.05).Multiple regression analysis revealed that gender,oxygen saturation and MMSE scores were risk factors of depression (P ＜ 0.05).MMSE scores decreased more obviously in the COPD patients with depression and were positively correlated with oxygen saturation (P ＜ 0.01).A negative correlation existed between MMSE scores and HAMD scores (r =-0.549,P ＜ 0.05).