CAJ | 학술논문

目的探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者体内植物凝集素样氧化低密度脂蛋白受体-1(LOX-1)及血脂的水平.方法对2011年1月-7月间具有睡眠障碍症状的门诊患者94例进行多导睡眠图(PSG)监测,根据睡眠呼吸暂停低通气指数(AHI)分为3组,轻中度OSAHS组(5次/h≤AHI≤30次/h)27例,重度OSAHS组(AHI＞ 30次/h)37例,正常对照组(AHI＜5次/h)30例,均检测血清LOX-1、TG、TC、HDL-C、LDL-C.结果重度OSAHS组血清LOX-1水平最高,轻中度组、正常对照组依次减低,差异有统计学意义(P＜0.01).OSAHS患者血清LOX-1水平与AHI、夜间最长呼吸暂停时间(LAT)呈正相关(r值分别为0.645、0.501,P＜0.01),与夜间最低血氧饱和度(SaO2)呈负相关(r=-0.647,P＜0.01).OSAHS组患者血脂水平与正常对照组差异无统计学意义(P＞0.05).结论 OSAHS所造成的夜间间歇缺氧可导致血清LOX-1水平升高,血脂水平不能有效预测OSAHS患者脂代谢紊乱的程度.
목적 탐토불동정도조새성수면호흡잠정저통기종합정(OSAHS)환자체내식물응집소양양화저밀도지단백수체-1(LOX-1)급혈지적수평.방법 대2011년1월-7월간구유수면장애증상적문진환자94례진행다도수면도(PSG)감측,근거수면호흡잠정저통기지수(AHI)분위3조,경중도OSAHS조(5차/h≤AHI≤30차/h)27례,중도OSAHS조(AHI＞ 30차/h)37례,정상대조조(AHI＜5차/h)30례,균검측혈청LOX-1、TG、TC、HDL-C、LDL-C.결과 중도OSAHS조혈청LOX-1수평최고,경중도조、정상대조조의차감저,차이유통계학의의(P＜0.01).OSAHS환자혈청LOX-1수평여AHI、야간최장호흡잠정시간(LAT)정정상관(r치분별위0.645、0.501,P＜0.01),여야간최저혈양포화도(SaO2)정부상관(r=-0.647,P＜0.01).OSAHS조환자혈지수평여정상대조조차이무통계학의의(P＞0.05).결론 OSAHS소조성적야간간헐결양가도치혈청LOX-1수평승고,혈지수평불능유효예측OSAHS환자지대사문란적정도.
Objective To explore the changes of serum lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and the level of lipids in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 94 candidates with sleep disorders between January-July 2011 at outpatient department were monitored with polysomnography.According to apnea-hypopnea index (AHI),they were divided into mild-to-moderate OSAHS (5 ≤ AHI ≤ 30) (n =27),severe OSAHS (AHI ＞ 30) (n =37) and normal control groups (AHI ＜ 5) (n =30).After polysomnography,their blood samples were obtained to measure the levels of serum LOX-1,triglycerides (TG),cholesterol (TC),high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).Results The serum level of LOX-1 in severe OSAHS group was significantly higher than that in the mild-to-moderate and control groups (P ＜ 0.01).The serum level of LOX-1 in OSAHS patients was positively correlated with AHI and longest apnea time (LAT)(r =0.645 & 0.501 respectively,both P ＜ 0.01) and was negatively correlated with SaO2 (r =-0.647,P ＜0.01).No significant difference existed in serum lipids in all groups (P ＞ 0.05).Conclusions Intermittent hypoxia caused by OSAHS increases the level of LOX-1 to further promote the formation and development of atherosclerotic in patients with OSAHS.The levels of lipid can not effectively predict the severity of lipid metabolism disorder in patients with OSAHS.