CAJ | 학술논문

目的调查35岁以上汉、维吾尔族自然人群阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者2型糖尿病(T2DM)的患病率,探讨OSAHS与T2DM的关系.方法 2010年至2012年间,对克拉玛依市区天山社区755例35岁以上(汉族398例,维吾尔族357例)鼾症患者进行睡眠呼吸血氧监测(呼吸暂停低通气指数,氧减饱和度指数,夜间平均血氧饱和度,夜间最低血氧饱和度)和空腹血糖测定.按睡眠监测结果分为汉族OSAHS组(279例)和维吾尔族OSAHS组(226例),两组年龄、性别匹配,组间进行各项参数比较.体检项目包括身高、体重、颈围、腰围.结果汉族与维吾尔族鼾症组间BMI分别为(24.9±3.2)和(28.2± 4.4) kg/m2,颈围分别为(35.2±3.2)和(37.4±3.4)cm,腰围分别为(87.1±9.5)和(98.0±11.6)cm,氧减饱和度指数分别为(9.9±0.5)和(8.2±0.4)次/h,夜间最低血氧饱和度分别为(83.3±6.9)％和(82.7±7.4)％,呼吸暂停低通气指数分别为(15.0±14.3)和(11.9±11.4)次/h,空腹血糖分别为(6.3±1.4)和(7.1±2.8)mmol/L,组间比较差异均有统计学意义(P＜0.05).维吾尔族与汉族OSAHS组间T2DM患病率[30.5％(69/226)和16.8％ (47/279)]差异有统计学意义(P＜0.05).多因素logistic回归分析显示,年龄(OR=1.667)、呼吸紊乱指数(OR=2.074)和民族(OR=1.922)是T2DM患病的主要危险因素.结论维吾尔族OSAHS患者T2DM患病率高于汉族,年龄、民族、呼吸暂停低通气指数是T2DM的患病高危因素,T2DM与OSAHS相关.
목적 조사35세이상한、유오이족자연인군조새성수면호흡잠정저통기종합정(OSAHS)환자2형당뇨병(T2DM)적환병솔,탐토OSAHS여T2DM적관계.방법 2010년지2012년간,대극랍마의시구천산사구755례35세이상(한족398례,유오이족357례)한증환자진행수면호흡혈양감측(호흡잠정저통기지수,양감포화도지수,야간평균혈양포화도,야간최저혈양포화도)화공복혈당측정.안수면감측결과분위한족OSAHS조(279례)화유오이족OSAHS조(226례),량조년령、성별필배,조간진행각항삼수비교.체검항목포괄신고、체중、경위、요위.결과 한족여유오이족한증조간BMI분별위(24.9±3.2)화(28.2± 4.4) kg/m2,경위분별위(35.2±3.2)화(37.4±3.4)cm,요위분별위(87.1±9.5)화(98.0±11.6)cm,양감포화도지수분별위(9.9±0.5)화(8.2±0.4)차/h,야간최저혈양포화도분별위(83.3±6.9)％화(82.7±7.4)％,호흡잠정저통기지수분별위(15.0±14.3)화(11.9±11.4)차/h,공복혈당분별위(6.3±1.4)화(7.1±2.8)mmol/L,조간비교차이균유통계학의의(P＜0.05).유오이족여한족OSAHS조간T2DM환병솔[30.5％(69/226)화16.8％ (47/279)]차이유통계학의의(P＜0.05).다인소logistic회귀분석현시,년령(OR=1.667)、호흡문란지수(OR=2.074)화민족(OR=1.922)시T2DM환병적주요위험인소.결론 유오이족OSAHS환자T2DM환병솔고우한족,년령、민족、호흡잠정저통기지수시T2DM적환병고위인소,T2DM여OSAHS상관.
Objective To explore the prevalence of diabetes in obstructive sleep apnea-hypopnea syndrome (OSAHS) adults over 35 years old of Han and Uygur nationalities and elucidate the relationship between sleep apnea and type 2 diabetes mellitus.Methods From 2010 to 2012,A total of 755 subjects aged ≥35 years (Han,n =398; Uygur,n =357) were selected from a natural population in Tianshan District of Kelamayi,Xinjiang Autonomous Region.Height,weight,neck circumference,abdominal circumference and blood sugar were measured.And all subjects of snoring underwent respiration and pulse oximeter tests.Apnea-hypopnea index (AHI),mean SaO2 (MSaO2 ％),lowest SaO2 (LSaO2 ％) and the number of desaturations ≥4％ per hour (ODI4) were calculated.They were divided into OSAHS and non OSAHS groups.Both Han nationality and Uygur nationality groups were matched for age and gender.Results The parameters of body mass [(24.9 ± 3.2) vs.(28.2 ± 4.4) kg/m2],neck circumference [(35.2 ± 3.2) vs.(37.4 ± 3.4) cm],abdominal circumference [(87.1 ± 9.5) vs.(98.0 ± 11.6) cm],oxygen desaturation index [(9.9 ±0.5) vs.(8.2 ± 0.4)/h],nadir arterial oxygen saturation [(83.3 ±6.9) ％ vs.(82.7 ± 7.4) ％],apnea-hypopnea index [(15.0 ± 14.3) vs.(11.9 ± 11.4)/h] and blood sugar [(6.3 ± 1.4) vs.(7.1 ± 2.8) mmol/L] were significantly different between Han and Uygur nationality snoring groups (P ＜ 0.05).Significant difference existed in the prevalence of diabetes in OSAHS groups between Han and Uygur nationalities [16.8％ (47/279) vs.30.5％ (69/226)] (P ＜ 0.05).Logistic regression analysis revealed that age (OR =1.667),apnea-hypopnea index (AHI) (OR =2.074) and nationality (OR =1.922) were major risk factors for diabetes.The prevalence of diabetes for OSAHS was 19.3％ (69/357) in Uygur nationality versus 11.8％ (47/398) in Han nationality.Conclusion The prevalence of diabetes for OSAHS in Uygur nationality is higher than that in Han nationality.The high-risk diabetic factors are age,nationality and AHI.And a close relationship exists between type 2 diabetes mellitus and sleep apnea.