CAJ | 학술논문

目的探讨肾活检在2型糖尿病伴有肾脏损害时诊断的意义.方法分析接受肾活检的81例2型糖尿病患者合并肾脏损害患者的病理改变特点,临床特征.结果肾穿刺结果显示,44例(54％)2型糖尿病患者合并菲糖尿病性肾脏疾病,32例(40％)肾损害为糖尿病肾病,5例(6％)为糖尿病肾病合并非糖尿病性肾脏疾病.非糖尿病性病变组与糖尿病肾病组在糖尿病病程、血肌酐、镜下血尿、眼底改变、心血管系统改变等方面差异具有统计学意义(P＜0.05),而在其他方面差异无统计学意义.肾损害为非糖尿病性病变组,与同时存在糖尿病肾病和非糖尿病性肾病组在血肌酐、镜下血尿、心血管系统改变方面差异有统计学意义(P＜0.05),而在年龄、血压、24 h尿蛋白等方面无统计学意义.结论糖尿病合并非糖尿病性肾脏疾病与糖尿病肾病、糖尿病肾病合并非糖尿病性肾脏疾病间通过临床及实验室资料难以做出鉴别,肾活检对诊断具有重要价值.
목적 탐토신활검재2형당뇨병반유신장손해시진단적의의.방법 분석접수신활검적81례2형당뇨병환자합병신장손해환자적병리개변특점,림상특정.결과 신천자결과현시,44례(54％)2형당뇨병환자합병비당뇨병성신장질병,32례(40％)신손해위당뇨병신병,5례(6％)위당뇨병신병합병비당뇨병성신장질병.비당뇨병성병변조여당뇨병신병조재당뇨병병정、혈기항、경하혈뇨、안저개변、심혈관계통개변등방면차이구유통계학의의(P＜0.05),이재기타방면차이무통계학의의.신손해위비당뇨병성병변조,여동시존재당뇨병신병화비당뇨병성신병조재혈기항、경하혈뇨、심혈관계통개변방면차이유통계학의의(P＜0.05),이재년령、혈압、24 h뇨단백등방면무통계학의의.결론 당뇨병합병비당뇨병성신장질병여당뇨병신병、당뇨병신병합병비당뇨병성신장질병간통과림상급실험실자료난이주출감별,신활검대진단구유중요개치.
Objective To analyze the relationship between pathological diagnosis and clinical manifestation and elucidate the significance of renal biopsy on the diagnosis of type 2 diabetics complicated with non-diabetic renal disease (NDRD).Methods The clinicopathological data of 81 type 2 diabetics complicated with renal injury underwent renal biopsy.Results Patients with type 2 diabetic mellitus (DM) or diabetic nephropathy (DN) might be complicated with various kinds of non-diabetic renal injury.Among them,44 subjects (54％) with type 2 diabetes complicated with NDRD were classified as group A,32 cases (40％) with DN only group B and the remaining 5 cases (6％) with DN complicated with NDRD group C.Their pathological characteristics paralleled the clinical manifestations of renal disease.Conclusion It is difficult to differentiate patients with DM complicated with NDRD,DN,or DN complicated with NDRD.Therefore renal biopsy is an important differentiating method for analyzing renal pathological types and changes of patients.