CAJ | 학술논문

2006年1月至2012年12月在我科住院的60例持续肺动脉高压患儿,试验组32例,采用高频通气联合西地那非,对照组28例,采用单纯高频通气治疗,比较两组疗效.治疗后3d研究组与对照组肺动脉平均压分别为(32.4±5.7) mm Hg(1 mm Hg=0.133 kPa)比(43.1±8.6)mm Hg,二氧化碳分压分别为(35.8±8.6)mm Hg比(43.1±8.6) mm Hg,氧合指数分别为(55.8±21.8)比(85.3±20.6)(P＜0.05),动脉氧分压分别为(88.9±14.6)mm Hg比(71.6±21.7) mm Hg,PaOJFiO2分别为(223.5±18.0)mm Hg比(196.1±24.1)mm Hg,均高于对照组(P＜0.05).研究组上机时间短于对照组(P＜0.05),总有效率高于对照组(P＜0.05).高频通气联合西地那非治疗重度持续肺动脉高压可有效降低肺动脉压力,缩短上机时间,提高治愈率.
2006년1월지2012년12월재아과주원적60례지속폐동맥고압환인,시험조32례,채용고빈통기연합서지나비,대조조28례,채용단순고빈통기치료,비교량조료효.치료후3d연구조여대조조폐동맥평균압분별위(32.4±5.7) mm Hg(1 mm Hg=0.133 kPa)비(43.1±8.6)mm Hg,이양화탄분압분별위(35.8±8.6)mm Hg비(43.1±8.6) mm Hg,양합지수분별위(55.8±21.8)비(85.3±20.6)(P＜0.05),동맥양분압분별위(88.9±14.6)mm Hg비(71.6±21.7) mm Hg,PaOJFiO2분별위(223.5±18.0)mm Hg비(196.1±24.1)mm Hg,균고우대조조(P＜0.05).연구조상궤시간단우대조조(P＜0.05),총유효솔고우대조조(P＜0.05).고빈통기연합서지나비치료중도지속폐동맥고압가유효강저폐동맥압력,축단상궤시간,제고치유솔.
A total of 60 infants with severe persistent pulmonary hypertension (PPHN) at our NICU from January 2006 to December 2012 were divided into research group[(n =32,high-frequency oscillatory ventilation(HFOV) plus sildenafil)]and control group (n =28,HFOV only).Mean pulmonary arterial pulmonary arterial (MPAP),blood gas analysis,oxygenation index (OI),PO2 to fraction of inspired oxygen ratio (PO2/FiO2) before and after treatment were compared between two groups.After 3-day treatment,MPAP (mm Hg)(32 ±6) vs.(43 ±9)mm Hg,PCO2(mm Hg)(36 ±9) vs.(43 ±9),OI(56 ±22) vs.(85 ±21) in research group were significantly lower than those in control group(P ＜ 0.05) ; in comparison with control group,PO2(mm Hg) (89 ±15) vs.(72 ±22),PO2/FiO2(mm Hg) (223 ± 18) vs.(196 ±24) in research group were significantly higher(P ＜ 0.05).The time of ventilation use (d) (5.4 ± 1.3) vs.(6.3 ± 1.6) in research group was shorter than that of control group(P ＜0.05) while research group showed a higher clinical efficiency rate(％) (81.2 vs.50.0) (P ＜0.05).A combination of HFOV and sildenafil for severe PPHN can significantly reduce MPAP,shorten the duration of ventilation use and improve cure rate.