CAJ | 학술논문

采用电化学发光法和酶联免疫法检测111例非小细胞肺癌、103例肺部良性疾病、97例正常人糖类抗原125(CA125)、血清细胞角蛋白19(CYFRA21-1)、组织多肽抗原(TPA)、人鳞状细胞癌相关抗原(SCC-Ag)的水平.非小细胞肺癌患者CA125、CYFRA21-1、SCC、TPA水平明显高于正常人和肺部良性疾病患者(P＜0.01)；四项联合检测的敏感性及特异度均明显高于单项检测；其测定水平与临床分期、病理类型和分化程度相关.
채용전화학발광법화매련면역법검측111례비소세포폐암、103례폐부량성질병、97례정상인당류항원125(CA125)、혈청세포각단백19(CYFRA21-1)、조직다태항원(TPA)、인린상세포암상관항원(SCC-Ag)적수평.비소세포폐암환자CA125、CYFRA21-1、SCC、TPA수평명현고우정상인화폐부량성질병환자(P＜0.01)；사항연합검측적민감성급특이도균명현고우단항검측；기측정수평여림상분기、병리류형화분화정도상관.
The pre-treatment serum levels of carbohydrate antigen 125 (CA125),cytokeratin 19 fragment 21-1 (CYFRA21-1),squamous carcinoma associated antigen (SCC-Ag),and tissue polypeptide antigen (TPA) were measured in 111 patients with primary non-small-cell lung cancer.And 103 benign lung disease cases and 97 healthy volunteers were also studied as controls.Enzyme linked immunosorbent assay (ELISA) was employed to detect the serum contents of SCC-Ag and TPA.The levels of CA125 and CYFRA21-1 were measured by electrochemical luminescence.The serum level of CYFRA21-1,SCC,TPA and CA125 in cancer patients were significantly higher than those of normal control and benign disease groups (P ＜ 0.01).The combined detection of tumor markers could significantly improve the sensitivity and specificity.And the levels of tumor markers were also correlated with the clinical stages and differentiation degrees.