中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2013年
1期
37-41
,共5页
杨婷婷%龙吟%江婵娟%孙中武
楊婷婷%龍吟%江嬋娟%孫中武
양정정%룡음%강선연%손중무
痴呆,血管性%认知障碍%抑郁
癡呆,血管性%認知障礙%抑鬱
치태,혈관성%인지장애%억욱
Dementia,vascular%Cognition disorders%Depression
目的 探讨皮质下缺血性血管病(SIVD)认知损害程度和抑郁的交互影响.方法 采用多种神经心理学量表对150例SIVD患者认知损害和抑郁情况进行评估.根据诊断标准,将受试者分为SIVD无认知损害组(SIVD-NCI)、SIVD轻度认知损害组(SIVD-MCI)和SIVD痴呆组(SIVD-D)；根据临床症状和老年抑郁量表(GDS)评分,将全部受试者分为无抑郁组(GDS≤10分)和抑郁组(GDS＞ 10分).使用协方差分析(ANCOVA)研究SIVD认知损害和抑郁的交互作用.结果 认知损害程度的主效应在所有剑桥老年认知量表(CAMCOG-C)子项中均有统计学意义；抑郁的主效应在大部分CAMCOG-C子项中也有统计学意义,而二者的交互作用仅在执行(F=6.835,P=0.001)、注意(F =3.126,P=0.047)、语言总分(F=3.352,P=0.038)和语言理解(F =5.324,P=0.006)中具有统计学意义.SIVD-NCI组与SIVD-MCI组之间,执行(F=14.255,P=0.000)、语言理解(F=3.971,P =0.049)呈现明显的认知损害和抑郁症状的交互作用；SIVD-MCI组与SIVD-D组之间,注意(F=4.918,P=0.030)呈现明显的认知损害和抑郁症状的交互作用.结论 SIVD患者存在不同程度的认知功能损害和抑郁症状；伴有抑郁的SIVD患者存在更为明显的认知功能损害；认知损害和抑郁存在交互影响；这种影响在不同的认知损害阶段发生于不同的认知区域.
目的 探討皮質下缺血性血管病(SIVD)認知損害程度和抑鬱的交互影響.方法 採用多種神經心理學量錶對150例SIVD患者認知損害和抑鬱情況進行評估.根據診斷標準,將受試者分為SIVD無認知損害組(SIVD-NCI)、SIVD輕度認知損害組(SIVD-MCI)和SIVD癡呆組(SIVD-D)；根據臨床癥狀和老年抑鬱量錶(GDS)評分,將全部受試者分為無抑鬱組(GDS≤10分)和抑鬱組(GDS＞ 10分).使用協方差分析(ANCOVA)研究SIVD認知損害和抑鬱的交互作用.結果 認知損害程度的主效應在所有劍橋老年認知量錶(CAMCOG-C)子項中均有統計學意義；抑鬱的主效應在大部分CAMCOG-C子項中也有統計學意義,而二者的交互作用僅在執行(F=6.835,P=0.001)、註意(F =3.126,P=0.047)、語言總分(F=3.352,P=0.038)和語言理解(F =5.324,P=0.006)中具有統計學意義.SIVD-NCI組與SIVD-MCI組之間,執行(F=14.255,P=0.000)、語言理解(F=3.971,P =0.049)呈現明顯的認知損害和抑鬱癥狀的交互作用；SIVD-MCI組與SIVD-D組之間,註意(F=4.918,P=0.030)呈現明顯的認知損害和抑鬱癥狀的交互作用.結論 SIVD患者存在不同程度的認知功能損害和抑鬱癥狀；伴有抑鬱的SIVD患者存在更為明顯的認知功能損害；認知損害和抑鬱存在交互影響；這種影響在不同的認知損害階段髮生于不同的認知區域.
목적 탐토피질하결혈성혈관병(SIVD)인지손해정도화억욱적교호영향.방법 채용다충신경심이학량표대150례SIVD환자인지손해화억욱정황진행평고.근거진단표준,장수시자분위SIVD무인지손해조(SIVD-NCI)、SIVD경도인지손해조(SIVD-MCI)화SIVD치태조(SIVD-D)；근거림상증상화노년억욱량표(GDS)평분,장전부수시자분위무억욱조(GDS≤10분)화억욱조(GDS＞ 10분).사용협방차분석(ANCOVA)연구SIVD인지손해화억욱적교호작용.결과 인지손해정도적주효응재소유검교노년인지량표(CAMCOG-C)자항중균유통계학의의；억욱적주효응재대부분CAMCOG-C자항중야유통계학의의,이이자적교호작용부재집행(F=6.835,P=0.001)、주의(F =3.126,P=0.047)、어언총분(F=3.352,P=0.038)화어언리해(F =5.324,P=0.006)중구유통계학의의.SIVD-NCI조여SIVD-MCI조지간,집행(F=14.255,P=0.000)、어언리해(F=3.971,P =0.049)정현명현적인지손해화억욱증상적교호작용；SIVD-MCI조여SIVD-D조지간,주의(F=4.918,P=0.030)정현명현적인지손해화억욱증상적교호작용.결론 SIVD환자존재불동정도적인지공능손해화억욱증상；반유억욱적SIVD환자존재경위명현적인지공능손해；인지손해화억욱존재교호영향；저충영향재불동적인지손해계단발생우불동적인지구역.
Objective To explore the relationship of cognitive impairment and depression in subcortical ischemic vascular disease (SIVD).Methods Neuropsychological scales were used to investigate the level of cognitive impairment and depression syndrome.According to the diagnostic criteria,the participants were divided into three groups:non-cognitive impairment group (SIVD-NCI),mild cognitive impairment group (SIVD-MCI),and dement group (SIVD-D).Depending on the clinical syndrome and the Geriatric Depression Scale (GDS),the participants were divided into depression group and non-depression group.The interaction of cognitive impairment and depression was analyzed using Analysis of Covariance (ANCOVA).Results The main effect of cognitive impairment was significant in all the Cambridge Cognitive Examination-Chinese version (CAMCOG-C) subscales,while the major function of depression in most of the CAMCOG-C subscales.The interaction of cognitive impairment and depression was significant only in executive function (F =6.835,P =0.001),attention (F =3.126,P =0.047),language (F =3.352,P =0.038) and comprehension of language (F =5.324,P =0.006).The interaction of cognitive impairment and depression was significant in executive function(F =14.255,P =0.000) and comprehension of language (F =3.971,P =0.049) between SIVD-NCI group and SIVD-MCI group while in attention (F =4.918,P =0.030) between SIVD-MCI group and SIVD-D group.Conclusions Patients of SIVD have varying degrees of cognitive impairment and depressive symptoms.Those with depression symptoms have more cognitive impairment than non-depressed patients.Cognitive impairment and depression show interaction in different subscales of cognitive function in different time.
