中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2013年
9期
592-596
,共5页
舒崖清%邱伟%郑雪平%陆正齐%陈健宁%胡学强
舒崖清%邱偉%鄭雪平%陸正齊%陳健寧%鬍學彊
서애청%구위%정설평%륙정제%진건저%호학강
组织细胞坏死性淋巴结炎%脑膜炎%抗体,抗核%核糖核蛋白类%免疫球蛋白G
組織細胞壞死性淋巴結炎%腦膜炎%抗體,抗覈%覈糖覈蛋白類%免疫毬蛋白G
조직세포배사성림파결염%뇌막염%항체,항핵%핵당핵단백류%면역구단백G
Histiocytic necrotizing lymphadenitis%Meningitis%Antibodies,antinuclear%Ribonucleoproteins%Immunoglobulin G
目的 探讨坏死性淋巴结炎(又称Kikuchi-Fujimoto病,KD)伴发脑膜炎患者的临床特点.方法 总结国内1例以脑膜炎为首发症状且免疫异常的KD患者的临床资料和诊疗经过,同时系统性回顾了国内外所报道的伴有脑膜炎的KD患者19例(包括本例),分析其性别、年龄、免疫指标、临床表现、病毒感染及治疗情况.结果 本例病例为25岁女性患者,伴有血抗核抗体、抗核糖核蛋白阳性,予激素治疗后治愈且未复发.分析全部19例病例,平均年龄为20.2岁,性别(男∶女)比为9:10,7例患者血清免疫异常,7例以脑膜炎为首发症状,5例用激素治疗.结论 伴发脑膜炎的KD发病年龄较普通KD更早,男女比例接近,淋巴结活体组织检查是目前确诊该病的惟一方法.
目的 探討壞死性淋巴結炎(又稱Kikuchi-Fujimoto病,KD)伴髮腦膜炎患者的臨床特點.方法 總結國內1例以腦膜炎為首髮癥狀且免疫異常的KD患者的臨床資料和診療經過,同時繫統性迴顧瞭國內外所報道的伴有腦膜炎的KD患者19例(包括本例),分析其性彆、年齡、免疫指標、臨床錶現、病毒感染及治療情況.結果 本例病例為25歲女性患者,伴有血抗覈抗體、抗覈糖覈蛋白暘性,予激素治療後治愈且未複髮.分析全部19例病例,平均年齡為20.2歲,性彆(男∶女)比為9:10,7例患者血清免疫異常,7例以腦膜炎為首髮癥狀,5例用激素治療.結論 伴髮腦膜炎的KD髮病年齡較普通KD更早,男女比例接近,淋巴結活體組織檢查是目前確診該病的惟一方法.
목적 탐토배사성림파결염(우칭Kikuchi-Fujimoto병,KD)반발뇌막염환자적림상특점.방법 총결국내1례이뇌막염위수발증상차면역이상적KD환자적림상자료화진료경과,동시계통성회고료국내외소보도적반유뇌막염적KD환자19례(포괄본례),분석기성별、년령、면역지표、림상표현、병독감염급치료정황.결과 본례병례위25세녀성환자,반유혈항핵항체、항핵당핵단백양성,여격소치료후치유차미복발.분석전부19례병례,평균년령위20.2세,성별(남∶녀)비위9:10,7례환자혈청면역이상,7례이뇌막염위수발증상,5례용격소치료.결론 반발뇌막염적KD발병년령교보통KD경조,남녀비례접근,림파결활체조직검사시목전학진해병적유일방법.
Objective To explore the clinical characteristics in patients with histiocytic necrotizing lymphadenitis (also called Kikuchi-Fujimoto' s disease,KD) and meningitis.Methods We reported a patient who developed meningitis preceding the other presentations of KD with abnormal serum autoimmune phenomena,and systematically reviewed 19 cases of KD with meningitis that had been reported worldwide,and analyzed the clinical parameters and treatments.Results The present case was a 25-year-old female subject with serum antinuclear factor antibody and anti-ribonucleoprotein antibody positive.The patient recovered after treatment with steroid and no recurrence was appeared.Among the 19 patients,the average age was 20.2 years,sex ratio was 10:9 (10 female:9 male),7 patients had abnormal serum autoimmune phenomena,7 patients'initial symptom was meningitis and 5 patients were administrated with steroid.Conclusions The onset age in KD with meningitis is earlier than the common KD,and sex ratio in KD with meningitis is close to 1∶ 1.A definitive diagnosis of the disease is determined by a lymph node biopsy at present.