中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2014年
7期
491-495
,共5页
孟新玲%刘婷%刘远新%马娜%沙拉·胡吉肯%雍雨暄%杜帅%沙迪克·沙吾提
孟新玲%劉婷%劉遠新%馬娜%沙拉·鬍吉肯%雍雨暄%杜帥%沙迪剋·沙吾提
맹신령%류정%류원신%마나%사랍·호길긍%옹우훤%두수%사적극·사오제
阿尔茨海默病%痴呆,血管性%患病率%抽样研究
阿爾茨海默病%癡呆,血管性%患病率%抽樣研究
아이자해묵병%치태,혈관성%환병솔%추양연구
Alzheimer disease%Dementia,vascular%Prevalence%Sampling studies
目的 了解新疆维吾尔自治区(简称新疆)哈萨克族及汉族老年期痴呆和阿尔茨海默病(AD)的患病率及其流行特征.方法 采用分层多级整群抽样方法,根据新疆独特的地理环境及哈萨克族主要居住地,依据随机数字表法随机抽取新疆北疆的阿勒泰地区15个乡镇哈萨克族、汉族2个民族≥55岁的调查对象3 663人.调查采用筛查和确诊两阶段法,根据国际统一的诊断标准,美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)的标准诊断痴呆,AD诊断采用美国神经病学、语言障碍和卒中-老年性痴呆和相关疾病学会(NINCDS-ADRDA)的标准,应用美国国立神经系统疾病与卒中研究所和瑞士神经科学研究国际协会的标准诊断血管性痴呆(VaD).结果 (1)哈萨克族、汉族AD粗患病率分别为5.88％(149/2 532)、4.45％ (48/1 078),经年龄构成标化,分别为5.64％、4.73％;VaD粗患病率分别为2.69％ (68/2 532)、1.95％ (21/1 078),标化率为2.43％、1.99％,两民族之间差异无统计学意义.(2)哈萨克族女性与男性AD患病率比较分别为7.32％ (96/1 311)、4.34％ (53/1 221),差异有统计学意义(x2=15.807,P＜0.01);汉族女性与男性AD患病率比较分别为6.02％(35/581)、2.62％ (13/497),差异具有统计学意义(x2=12.571,P＜0.01);无论是哈萨克族还是汉族,不同文化程度老年人AD患病率的差异均具有统计学意义;而相同文化程度、不同民族间AD患病率差异无统计学意义;两民族VaD患病率与文化程度无明显相关性.(3)两民族痴呆患病率随年龄增长急剧上升,特别是80岁以上人群AD患病率高达30.28％ (66/218).结论 AD是新疆哈萨克族和汉族老年人的主要痴呆类型,VaD次之;两民族中女性AD患病率明显高于男性;AD的患病率随文化程度的降低而升高;AD和VaD的患病率随着年龄的增长而增高.
目的 瞭解新疆維吾爾自治區(簡稱新疆)哈薩剋族及漢族老年期癡呆和阿爾茨海默病(AD)的患病率及其流行特徵.方法 採用分層多級整群抽樣方法,根據新疆獨特的地理環境及哈薩剋族主要居住地,依據隨機數字錶法隨機抽取新疆北疆的阿勒泰地區15箇鄉鎮哈薩剋族、漢族2箇民族≥55歲的調查對象3 663人.調查採用篩查和確診兩階段法,根據國際統一的診斷標準,美國精神障礙診斷與統計手冊第4版(DSM-Ⅳ)的標準診斷癡呆,AD診斷採用美國神經病學、語言障礙和卒中-老年性癡呆和相關疾病學會(NINCDS-ADRDA)的標準,應用美國國立神經繫統疾病與卒中研究所和瑞士神經科學研究國際協會的標準診斷血管性癡呆(VaD).結果 (1)哈薩剋族、漢族AD粗患病率分彆為5.88％(149/2 532)、4.45％ (48/1 078),經年齡構成標化,分彆為5.64％、4.73％;VaD粗患病率分彆為2.69％ (68/2 532)、1.95％ (21/1 078),標化率為2.43％、1.99％,兩民族之間差異無統計學意義.(2)哈薩剋族女性與男性AD患病率比較分彆為7.32％ (96/1 311)、4.34％ (53/1 221),差異有統計學意義(x2=15.807,P＜0.01);漢族女性與男性AD患病率比較分彆為6.02％(35/581)、2.62％ (13/497),差異具有統計學意義(x2=12.571,P＜0.01);無論是哈薩剋族還是漢族,不同文化程度老年人AD患病率的差異均具有統計學意義;而相同文化程度、不同民族間AD患病率差異無統計學意義;兩民族VaD患病率與文化程度無明顯相關性.(3)兩民族癡呆患病率隨年齡增長急劇上升,特彆是80歲以上人群AD患病率高達30.28％ (66/218).結論 AD是新疆哈薩剋族和漢族老年人的主要癡呆類型,VaD次之;兩民族中女性AD患病率明顯高于男性;AD的患病率隨文化程度的降低而升高;AD和VaD的患病率隨著年齡的增長而增高.
목적 료해신강유오이자치구(간칭신강)합살극족급한족노년기치태화아이자해묵병(AD)적환병솔급기류행특정.방법 채용분층다급정군추양방법,근거신강독특적지리배경급합살극족주요거주지,의거수궤수자표법수궤추취신강북강적아륵태지구15개향진합살극족、한족2개민족≥55세적조사대상3 663인.조사채용사사화학진량계단법,근거국제통일적진단표준,미국정신장애진단여통계수책제4판(DSM-Ⅳ)적표준진단치태,AD진단채용미국신경병학、어언장애화졸중-노년성치태화상관질병학회(NINCDS-ADRDA)적표준,응용미국국립신경계통질병여졸중연구소화서사신경과학연구국제협회적표준진단혈관성치태(VaD).결과 (1)합살극족、한족AD조환병솔분별위5.88％(149/2 532)、4.45％ (48/1 078),경년령구성표화,분별위5.64％、4.73％;VaD조환병솔분별위2.69％ (68/2 532)、1.95％ (21/1 078),표화솔위2.43％、1.99％,량민족지간차이무통계학의의.(2)합살극족녀성여남성AD환병솔비교분별위7.32％ (96/1 311)、4.34％ (53/1 221),차이유통계학의의(x2=15.807,P＜0.01);한족녀성여남성AD환병솔비교분별위6.02％(35/581)、2.62％ (13/497),차이구유통계학의의(x2=12.571,P＜0.01);무론시합살극족환시한족,불동문화정도노년인AD환병솔적차이균구유통계학의의;이상동문화정도、불동민족간AD환병솔차이무통계학의의;량민족VaD환병솔여문화정도무명현상관성.(3)량민족치태환병솔수년령증장급극상승,특별시80세이상인군AD환병솔고체30.28％ (66/218).결론 AD시신강합살극족화한족노년인적주요치태류형,VaD차지;량민족중녀성AD환병솔명현고우남성;AD적환병솔수문화정도적강저이승고;AD화VaD적환병솔수착년령적증장이증고.
Objective To investigate the morbidity and epidemiology of dementia in old people and Alzheimer's disease (AD) in Kazak and Han ethnic groups in Xinjiang Uygur Autonomous Region.Methods Using stratified cluster random sampling method,we conducted this survey within 3 663 subjects randomly selected from the residences (≥ 55 years old) including Kazak and Han ethnic groups in Aletai area,northern Xinjiang.The diagnosis of dementia was confirmed by the American Diagnostic and Statistical Manual of Mental Disorders (DSM-Ⅳ) based on two-stage investigation including screening and confirmed diagnosis.The diagnostic criteria of AD was according to the reference standards of the American Institute of Neurology,the Language Barrier and Stroke and the AD and Related Disorders Association (NINCDS-ADRDA).The diagnostic criteria of vascular dementia (VaD) was based on American National Institute of Neurological Disorders and Stroke Research Institute and the Swiss Neuroscience Research International Association (NINDS/AIREN).Results (1) The crude prevalence rates of AD in Kazak and Han ethnic groups were 5.88％ (149/2 532) and 4.45％ (48/1 078),respectively and the age-adjusted rates were 5.64％ and 4.73％,respectively.These two rates of VaD in Kazak and Han ethnic groups were 2.69％ (68/2 532) and 1.95％ (21/1 078),2.43％ and 1.99％,respectively.There were no significant differences between two ethnic groups.(2) The AD morbidity in female and male was 7.32％ (96/1 311) and 4.34％ (53/1 221 ; x2 =15.807,P ＜ 0.01) respectively in Kazak population; While it was 6.02％ (35/581) and 2.62％ (13/497; x2 =12.571,P ＜ 0.01) in Hans.The morbidity difference was statistically significant in different educational levels.However,there was no statistically significant difference in subjects with same degree of education.In VaD,there was no correlation between educational level and morbidity in both Kazak and Han people.(3) The morbidity of dementia was sharply increased with age in two populations,especially in patients over 80 years old with the highest of 30.28％ (66/218).Conclusions AD is the main type of dementia in old Kazak and Han people in Xinjiang,while VaD is the second reason of dementia.The morbidity rate of AD in female is significantly higher than men in both two ethnic groups.The lower level of education is associated with the higher incidence of AD and the morbidity of AD and VaD is increased with age.
