中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2014年
7期
501-504
,共4页
黄静%张玉虎%聂坤%冯淑君%朱睿明%甘蓉%唐红梅%王丽敏%赵洁皓
黃靜%張玉虎%聶坤%馮淑君%硃睿明%甘蓉%唐紅梅%王麗敏%趙潔皓
황정%장옥호%섭곤%풍숙군%주예명%감용%당홍매%왕려민%조길호
帕金森病%认知障碍%睡眠障碍%睡眠
帕金森病%認知障礙%睡眠障礙%睡眠
파금삼병%인지장애%수면장애%수면
Parkinson disease%Cognition disorders%Sleep disorders%Sleep
目的 比较帕金森病伴认知障碍患者与帕金森病认知正常患者睡眠质量的差异,并分析帕金森病患者睡眠与认知障碍之间可能存在的关系.方法 收集2012年2月至2013年10月在广东省人民医院神经科就诊的帕金森病患者共109例,进行MMSE、蒙特利尔认知评估量表(MoCA)、韦氏智力及记忆力的认知评估,根据评估结果将其分为认知障碍组46例,认知正常组63例.使用帕金森病睡眠评估量表-2(PDSS-2)、匹兹堡睡眠质量指数量表(PSQI)、Epworth嗜睡量表评估所有患者的睡眠情况.结果 认知障碍组比认知正常组的PDSS-2和PSQI总分高,差异具有统计学意义[分别为(23.88±13.00)分与(13.80 ±9.76)分,t=-3.745,P＜0.01;(10.58 ±4.89)分与(6.87±4.64)分,t=-3.269,P=0.001].认知障碍组的PDSS-2-2 ～6、9的评分较认知正常组高;PSQI各分项中,认知障碍组的睡眠质量[(1.76±1.00)分]、入睡时间[(1.42±1.09)分]、睡眠效率[(1.52±1.28)分]、睡眠障碍[(1.61±0.56)分]的评分较认知正常组[(1.04±0.85)、(0.91±1.08)、(0.89±1.17)、(1.25±0.65)分,t=-3.134,-2.286,-2.363,-2.590,均P＜0.05]高.MoCA评分与PDSS-2总分和PSQI总分呈负相关(r=-0.24,P=0.03;r=-0.23,P=0.04).结论 帕金森病伴认知障碍患者较认知正常患者存在明显的睡眠障碍.PDSS-2与PSQI相结合,可以初步了解帕金森病患者睡眠障碍的潜在原因和程度.
目的 比較帕金森病伴認知障礙患者與帕金森病認知正常患者睡眠質量的差異,併分析帕金森病患者睡眠與認知障礙之間可能存在的關繫.方法 收集2012年2月至2013年10月在廣東省人民醫院神經科就診的帕金森病患者共109例,進行MMSE、矇特利爾認知評估量錶(MoCA)、韋氏智力及記憶力的認知評估,根據評估結果將其分為認知障礙組46例,認知正常組63例.使用帕金森病睡眠評估量錶-2(PDSS-2)、匹玆堡睡眠質量指數量錶(PSQI)、Epworth嗜睡量錶評估所有患者的睡眠情況.結果 認知障礙組比認知正常組的PDSS-2和PSQI總分高,差異具有統計學意義[分彆為(23.88±13.00)分與(13.80 ±9.76)分,t=-3.745,P＜0.01;(10.58 ±4.89)分與(6.87±4.64)分,t=-3.269,P=0.001].認知障礙組的PDSS-2-2 ～6、9的評分較認知正常組高;PSQI各分項中,認知障礙組的睡眠質量[(1.76±1.00)分]、入睡時間[(1.42±1.09)分]、睡眠效率[(1.52±1.28)分]、睡眠障礙[(1.61±0.56)分]的評分較認知正常組[(1.04±0.85)、(0.91±1.08)、(0.89±1.17)、(1.25±0.65)分,t=-3.134,-2.286,-2.363,-2.590,均P＜0.05]高.MoCA評分與PDSS-2總分和PSQI總分呈負相關(r=-0.24,P=0.03;r=-0.23,P=0.04).結論 帕金森病伴認知障礙患者較認知正常患者存在明顯的睡眠障礙.PDSS-2與PSQI相結閤,可以初步瞭解帕金森病患者睡眠障礙的潛在原因和程度.
목적 비교파금삼병반인지장애환자여파금삼병인지정상환자수면질량적차이,병분석파금삼병환자수면여인지장애지간가능존재적관계.방법 수집2012년2월지2013년10월재광동성인민의원신경과취진적파금삼병환자공109례,진행MMSE、몽특리이인지평고량표(MoCA)、위씨지력급기억력적인지평고,근거평고결과장기분위인지장애조46례,인지정상조63례.사용파금삼병수면평고량표-2(PDSS-2)、필자보수면질량지수량표(PSQI)、Epworth기수량표평고소유환자적수면정황.결과 인지장애조비인지정상조적PDSS-2화PSQI총분고,차이구유통계학의의[분별위(23.88±13.00)분여(13.80 ±9.76)분,t=-3.745,P＜0.01;(10.58 ±4.89)분여(6.87±4.64)분,t=-3.269,P=0.001].인지장애조적PDSS-2-2 ～6、9적평분교인지정상조고;PSQI각분항중,인지장애조적수면질량[(1.76±1.00)분]、입수시간[(1.42±1.09)분]、수면효솔[(1.52±1.28)분]、수면장애[(1.61±0.56)분]적평분교인지정상조[(1.04±0.85)、(0.91±1.08)、(0.89±1.17)、(1.25±0.65)분,t=-3.134,-2.286,-2.363,-2.590,균P＜0.05]고.MoCA평분여PDSS-2총분화PSQI총분정부상관(r=-0.24,P=0.03;r=-0.23,P=0.04).결론 파금삼병반인지장애환자교인지정상환자존재명현적수면장애.PDSS-2여PSQI상결합,가이초보료해파금삼병환자수면장애적잠재원인화정도.
Objective To assess the sleep quality in the Parkinson's disease (PD) patients with cognitive impairment and to analyze the possible relationship between sleep disorders and cognitive impairment in PD patients.Methods One hundred and nine PD patients were assessed cognitive function using Mini-Mental State Examination (MMSE),Montreal Cognitive Assessment (MoCA) and Wechsler Intelligence Scale and Wechsler Memory Scale,and sleep quality was evaluated using the Parkinson's Disease Sleep Scale-2 (PDSS-2),Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale.All PD patients were divided into abnormal cognitive group (n =46) and normal cognitive group (n =63).Results PDSS-2 and PSQI scores were significantly higher in abnormal cognitive group than in normal cognitive group (23.88 ± 13.00 vs 13.80 ±9.76,t =-3.745,P ＜0.01 ; 10.58 ±4.89 vs 6.87 ±4.64,t =-3.269,P=0.001).The scores of PDSS-2 in PDSS-2-2,3,4,5,6,9 and PSQI in sleep quality (1.76 ± 1.00),sleep time (1.42 ± 1.09),sleep efficiency (1.52 ± 1.28) as well as sleep disorder (1.61 ± 0.56) were also significantly higher in abnormal cognitive group than in normal cognitive group (1.04 ± 0.85,0.91±1.08,0.89 ±1.17,1.25 ±0.65,t=-3.134,-2.286,-2.363,-2.590,all P＜ 0.05).The correlations between the scores of MoCA and PDSS-2,MoCA and PSQI were significant (r =-0.24,P =0.03 ; r =-0.23,P =0.04).Conclusions The PD patients with abnormal cognition have lower sleep quality than those with normal cognition.Combining PDSS-2 with PSQI could preliminarily understand the underlying causes and the degree of PD patients with sleep disorders.
