CAJ | 학술논문

目的总结颅内软骨肉瘤的临床特点、诊疗方法和预后,为进一步改进颅内尤其是颅底软骨肉瘤的诊疗提供依据.方法对26例经病理证实的软骨肉瘤患者进行随访及回顾性分析,对其临床特点、治疗方案和预后进行分析和评价.结果 26例中24例病变位于颅底,1例位于幕上,1例位于松果体区,均行手术治疗.7例全切,15例近全切,4例大部切除.12例术后行普通放疗或伽玛刀治疗,随访到22例,随访时间为6 -89个月(平均41个月),4例死亡,余18例中9例脑神经功能恢复正常,5例有轻度脑神经功能不全,4例脑神经功能较术前无改善或加重.结论颅内软骨肉瘤为恶性肿瘤,大部分源于颅底,首选手术治疗,术后选择性的行普通放疗或伽玛刀治疗,预后情况与肿瘤的切除程度及病理类型密切相关,大部分患者经积极治疗有较好的预后.
목적 총결로내연골육류적림상특점、진료방법화예후,위진일보개진로내우기시로저연골육류적진료제공의거.방법 대26례경병리증실적연골육류환자진행수방급회고성분석,대기림상특점、치료방안화예후진행분석화평개.결과 26례중24례병변위우로저,1례위우막상,1례위우송과체구,균행수술치료.7례전절,15례근전절,4례대부절제.12례술후행보통방료혹가마도치료,수방도22례,수방시간위6 -89개월(평균41개월),4례사망,여18례중9례뇌신경공능회복정상,5례유경도뇌신경공능불전,4례뇌신경공능교술전무개선혹가중.결론 로내연골육류위악성종류,대부분원우로저,수선수술치료,술후선택성적행보통방료혹가마도치료,예후정황여종류적절제정도급병리류형밀절상관,대부분환자경적겁치료유교호적예후.
Objective Through study the clinical characteristics,diagnosis,treatment and prognosis of intracranial chondrosarcoma,to improve the management of this disease. Methods The clinical data of 26 cases of intracranial chondrosarcoma confirmed by pathology from Nov.2004 to Sep.2011 were analyzed retrospectively,then the data of result were valued.Results 24 cases from skull base,1 case from supratentorial and 1 case from pineal region,they were all given operated.Of 26 cases,7 cases of totally resection,15 cases of sub - total resection and 4 cases of gross resection.Then the 12 cases were given radiotherapy.22 cases were followed up for 6 months to 89 months (mean 41 months),4 cases died,18 cases can recover daily life.Conclusions Intracranial chondrosarcoma are malignant tumors,and usually arise in skull base,surgery should be firstly performed,then the radiotherapy can be selected in some cases.The prognosis is related to the degree of resection and pathology.Most of cases can have a better outcome though the active therapy.