脑中心疝动物模型的建立
뇌중심산동물모형적건립
Animal Models of brain central herniation
  • 万方数据
    中华神经外科杂志 중화신경외과잡지
    Chinese Journal of Neurosurgery
    2012年 9期 953-956 ,共4页

    胡旭%董吉荣%蔡学见%王玉海%时忠华%刘斌%徐勤义%蔡桑%陈克非%金东%施栋良%何建青%吴耀义

    호욱%동길영%채학견%왕옥해%시충화%류빈%서근의%채상%진극비%금동%시동량%하건청%오요의

    脑疝%模型,动物%颅内高压%病理学 腦疝%模型,動物%顱內高壓%病理學
    뇌산%모형,동물%로내고압%병이학
    Encephalocele%Models,animal%Intracranial hypertension%Pathology
    目的 建立脑中心疝的动物模型并模拟其临床分期.方法 采用额底放置球囊逐渐注水的方法建立兔子脑中心疝模型,结合临床分期特点观察脑疝形成后颅内压、脑灌注压、生命体征、影像学及病理学等变化.结果 脑中心疝模型建立后,各项观察指标在各期内均出现特异性变化,与临床上相符.结论 本体系可用于建立和明确脑中心疝各期情况,为深入研究中心疝各期病理生理变化机制和临床上有效治疗及预后判定奠定了基础.
    목적 건립뇌중심산적동물모형병모의기림상분기.방법 채용액저방치구낭축점주수적방법건립토자뇌중심산모형,결합림상분기특점관찰뇌산형성후로내압、뇌관주압、생명체정、영상학급병이학등변화.결과 뇌중심산모형건립후,각항관찰지표재각기내균출현특이성변화,여림상상상부.결론 본체계가용우건립화명학뇌중심산각기정황,위심입연구중심산각기병리생리변화궤제화림상상유효치료급예후판정전정료기출.
    Objective To establish a model of brain central herniation and simulate the clinical situation.Methods The rabbit brain central herniation model was established through inflating a balloon in the bottom of the frontal lobe,and combined with the characteristics of clinical stage to observe changes in intracranial pressure,cerebral perfusion pressure,vital signs,imaging and pathology after the formation of cerebral hernia.Results After establishment of central herniation model,the changes of observed indexes were significant and consisted with the clinical symptoms in each period.Conclusion This model can be used to establish and definite each stage of the brain central hernia,and lays a foundation of further research of center hernia about mechanisms of pathophysiology,clinical treatment and prognosis.
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