CAJ | 학술논문

目的探讨Kadish C期嗅神经母细胞瘤合理的治疗方法.方法回顾性分析6例Kadish C期嗅神经母细胞瘤的临床资料.均采取以手术为主,结合放疗、化疗或同步放化疗等措施的综合治疗.其中3例为初治病例,3例为复发病例.6例术中送冰冻病理,切缘均阴性.结果 5例整块全切除的患者随访20个月以上,无复发；1例分块全切除的患者,术后11个月死于肿瘤复发.并发症包括3例气颅,2例精神症状,1例脑脊液鼻漏.结论 Kadish C期嗅神经母细胞瘤治疗宜选择以手术为主的多学科综合治疗.手术可采用经额下入路,无瘤原则和颅底重建非常重要.
목적 탐토Kadish C기후신경모세포류합리적치료방법.방법 회고성분석6례Kadish C기후신경모세포류적림상자료.균채취이수술위주,결합방료、화료혹동보방화료등조시적종합치료.기중3례위초치병례,3례위복발병례.6례술중송빙동병리,절연균음성.결과 5례정괴전절제적환자수방20개월이상,무복발；1례분괴전절제적환자,술후11개월사우종류복발.병발증포괄3례기로,2례정신증상,1례뇌척액비루.결론 Kadish C기후신경모세포류치료의선택이수술위주적다학과종합치료.수술가채용경액하입로,무류원칙화로저중건비상중요.
Objective To investigate the treatment for Kadish stage C esthesioneuroblastoma.Method The medical recorders of six patients with Kadish stage C esthesioneuroblastoma were analyzed retrospectively.All were mainly treated with surgeries,combined with radiation therapy,chemotherapy,or chemoradiation.3 of 6 patients were first admitted,whereas the others were recurrence.Result Five patients with enbloc resection were followed up for more than 20 months with no tumor recurrence occurred.The patient performed piecemeal resection died of the recurrence in the 11st month after surgery.Complications included pneumocephalus in 3 cases,mental disturbance in 2,and CSF leakage in 1.Conclusion Kadish stage C esthesioneuroblastoma treatment needs surgical dominant multi-discipline treating pattern.Surgery can be performed via subfrontal approach.Tumor-free principle and skull base reconstruction are of great importance.