CAJ | 학술논문

目的验证清华大学航天航空学院自主研发的国产脑深部电刺激(DBS)系统用于治疗原发性帕金森病(PD)临床应用的安全性和有效性.方法对33例PD患者实施了国产脑深部电刺激系统(PINS系统)植入术.分别于术前、术后对用药情况,UPDRS评分量表,日常生活能力评分量表等情况进行评估和分析.结果 33例PD患者平均年龄(56.3±8.6)岁,平均病程(10.4±4.3)年.术后患者症状均得到显著改善,UPDRS运动评分较术前改善78％,症状控制稳定.结论国产脑深部电刺激器PINS系统生物安全性、系统稳定性、刺激作用有效性均能够满足临床应用的要求.
목적 험증청화대학항천항공학원자주연발적국산뇌심부전자격(DBS)계통용우치료원발성파금삼병(PD)림상응용적안전성화유효성.방법 대33례PD환자실시료국산뇌심부전자격계통(PINS계통)식입술.분별우술전、술후대용약정황,UPDRS평분량표,일상생활능력평분량표등정황진행평고화분석.결과 33례PD환자평균년령(56.3±8.6)세,평균병정(10.4±4.3)년.술후환자증상균득도현저개선,UPDRS운동평분교술전개선78％,증상공제은정.결론 국산뇌심부전자격기PINS계통생물안전성、계통은정성、자격작용유효성균능구만족림상응용적요구.
Objective To investigate the safety and efficacy of deep brain stimulation in idiopathic Parkinson's disease with domestic deep brain stimulation (DBS) systems,which were researched and developed by the School of Aerospace of Tsinghua University.Methods From November 2009 to December 2011,33 cases of patients with idiopathic Parkinson's disease were implanted with domestic deep brain stimulation system (PINS system) in Beijing Tiantan Hospital.During this study,preoperative,and 1,3,6,9,12 months postoperative assessments and analysis were done on each patient,which consisted of medication,UPDRS rating scale,and ADL Rating Scale situation.Results Among the 33 patients,The average age of them was 56.3 ± 8.6,mean duration of Parkinson's disease were 10.4 ± 4.3 years.Their symptoms of PD improved significantly postoperatively,which maintained consistently.Compared with base line,UPDRS motor scores with stimulation both of "off " state and "on" state had a reduction of 78 ％ and 78.8 ％ respectively 12 months after surgery.Conclusions Through the 12 months followed up of 33 cases of Parkinson's disease patients implanted with PINS system,the results confirmed the biological safety,stability and effectiveness of the PINS system,which was developed by the School of Acrospace,Tsinghua University.The resuhs also showed that PINS system has met the requirements of clinical applications.