CAJ | 학술논문

目的流行病学调查表明脑胶质瘤患者过敏反应的发生率降低,我们在脑胶质瘤患者血浆中检测了参与过敏反应的重要细胞因子白细胞介素-4,并探讨了血浆白细胞介素-4水平的临床意义.方法收集并检测了217例脑胶质瘤患者术前血浆样本中白细胞介素-4浓度,并评估了血浆白细胞介素-4水平与肿瘤级别和患者预后的关系.结果血浆白细胞介素-4水平在不同级别的脑胶质瘤患者间无明显差异.在Ⅳ级胶质瘤患者中血浆白细胞介素-4与患者生存期相关(HR0.296,95％ CI0.134 ～0.653,P=0.003).血浆白细胞介素-4高的患者生存期长于血浆白细胞介素-4低的患者但未达统计学意义(高白细胞介素-4和低白细胞介素-4生存期分别为31.92个月、20.55个月,P=0.079).在Ⅲ级胶质瘤患者中血浆白细胞介素-4与预后无明显相关.结论血浆白细胞介素-4与Ⅳ级胶质瘤患者预后相关,需要进一步扩大样本验证及研究其潜在的生物学机制及治疗价值.
목적 류행병학조사표명뇌효질류환자과민반응적발생솔강저,아문재뇌효질류환자혈장중검측료삼여과민반응적중요세포인자백세포개소-4,병탐토료혈장백세포개소-4수평적림상의의.방법 수집병검측료217례뇌효질류환자술전혈장양본중백세포개소-4농도,병평고료혈장백세포개소-4수평여종류급별화환자예후적관계.결과 혈장백세포개소-4수평재불동급별적뇌효질류환자간무명현차이.재Ⅳ급효질류환자중혈장백세포개소-4여환자생존기상관(HR0.296,95％ CI0.134 ～0.653,P=0.003).혈장백세포개소-4고적환자생존기장우혈장백세포개소-4저적환자단미체통계학의의(고백세포개소-4화저백세포개소-4생존기분별위31.92개월、20.55개월,P=0.079).재Ⅲ급효질류환자중혈장백세포개소-4여예후무명현상관.결론 혈장백세포개소-4여Ⅳ급효질류환자예후상관,수요진일보확대양본험증급연구기잠재적생물학궤제급치료개치.
Objective Epidemiology research has found less reported allergic condition in patients with gliomas.We tested plasma interleukin-4,which plays important role in allergic reaction,in patient with gliomas and determined its clinical significance.Methods A total of 217 patients with gliomas were studied.Plasma interleukin-4 concentration was determined and correlated with tumor grade and patients' survival.Results Plasma interleukin-4 did not have significant difference between gliomas with different pathological grades.In grade Ⅳ gliomas,plasma interleukin-4 was positively correlated with patients' survival time (HR 0.296,95％ CI 0.134 ～ 0.653,P =0.003).The patients with higher than median plasma interleukin-4 had longer survival time than the patients with low plasma interleukin-4 (high interleukin-4 vs.low interleukin-4,31.92 months vs.20.55 months,P =0.079).In grade Ⅲ glioma patients,this correlation was not significant.Conclusions Plasma interleukin-4 was correlated with patients' prognosis in grade Ⅳ gliomas.Further studies with expanded population and investigation on the underlying biological mechanisms are warranted.