CAJ | 학술논문

目的研究难治性癫痫患者中局灶性脑皮质发育不良(FCD)不同病理学类型与头皮脑电图(EEG)癫痫样放电形态之间的关系.方法选择术后病理学证实为FCD的难治性癫痫患者91例,头皮EEG间歇期癫痫样放电形态分为无癫痫样放电、棘波、多棘波和快节律四型.发作起始区EEG形态分为棘波、多棘波和(或)快节律、电位低减和不能分型四型.结果不同FCD类型头皮EEG间歇期癫痫样放电形态比较差异有统计学意义(P=0.013),其中FCDⅡa和FCDⅡb中多棘波多见;FCDⅡa中快节律多见,FCD Ⅰ和FCDⅢ中棘波多见.但发作起始区EEG形态与FCD类型无关(P =0.1976).结论 FCD所致的难治性癫痫中,FCD类型可能与头皮EEG间歇期癫痫样放电形态有关,对EEG癫痫样放电形态的分析可能会为FCD所致难治性癫痫的手术治疗提供依据..
목적 연구난치성전간환자중국조성뇌피질발육불량(FCD)불동병이학류형여두피뇌전도(EEG)전간양방전형태지간적관계.방법 선택술후병이학증실위FCD적난치성전간환자91례,두피EEG간헐기전간양방전형태분위무전간양방전、극파、다극파화쾌절률사형.발작기시구EEG형태분위극파、다극파화(혹)쾌절률、전위저감화불능분형사형.결과 불동FCD류형두피EEG간헐기전간양방전형태비교차이유통계학의의(P=0.013),기중FCDⅡa화FCDⅡb중다극파다견;FCDⅡa중쾌절률다견,FCD Ⅰ화FCDⅢ중극파다견.단발작기시구EEG형태여FCD류형무관(P =0.1976).결론 FCD소치적난치성전간중,FCD류형가능여두피EEG간헐기전간양방전형태유관,대EEG전간양방전형태적분석가능회위FCD소치난치성전간적수술치료제공의거..
Objective To study the relationship between different pathological types of focal cortical dysplasia (FCD) and the morphology of epileptiform discharges on electroencephalography (EEG) in patients with intractable epilepsy.Methods Case series of 91 patients (male∶ female =54∶37),aged 12.7 ± 9.76 years,with histo-pathological diagnosis of FCD (based on the consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission).All patients were examined by long-term scalp video EEG monitoring before operation and were followed up at least 6 months after operation.The morphology of the interictal discharges on scalp EEG were divided into 4 types including no epileptiform discharges,spikes,poly-spikes and fast rhythms.The morphology of the seizure onset was also divided into 4 types including spikes,poly-spikes and/or fast rhythms,electro-decremental and unclassified.Results Of 91 patients,there were significant difference between different types of FCD in the morphology of interictal discharges (P =0.013) with polyspikes more common in FCD Ⅱ a and FCD Ⅱ b and fast rhythms more common in FCD]] a and spikes more common in FCD Ⅰ and FCD Ⅲ.But no relationship was found between the morphology of the seizure onset and FCD types (P =0.1976).Conclusions In patients with FCD and intractable epilepsy,the morphology of interictal discharges in scalp EEG is probably related to the pathological types of FCD.