CAJ | 학술논문

目的明确破裂前期颅内动脉瘤的形态学及血流动力学特征,评估颅内动脉瘤的破裂风险因素.方法构建特异性破裂前期动脉瘤计算流体力学模型,并将其与破裂组后交通动脉动脉瘤进行了形态和血流动力学的数值模拟结果进行比较研究.结果破裂前期组与破裂组在形态学指标及瘤体低壁面切应力面积比(LSA)、瘤体剪切震荡指数(OSI)等血流动力学指标上差异无统计学意义,而破裂前期组平均瘤体壁面切应力(WSS)较破裂组显著降低(P=0.024);其中颈体比(AR)与LSA和OSI存在正相关关系,体径比(SR)与平均瘤体WSS存在负相关关系.结论处于破裂前期的颅内动脉瘤与破裂颅内动脉瘤有着相似形态学及血流动力学特征,较低的WSS和子囊的形成可能是促进动脉瘤破裂的重要因素.
목적 명학파렬전기로내동맥류적형태학급혈류동역학특정,평고로내동맥류적파렬풍험인소.방법 구건특이성파렬전기동맥류계산류체역학모형,병장기여파렬조후교통동맥동맥류진행료형태화혈류동역학적수치모의결과진행비교연구.결과 파렬전기조여파렬조재형태학지표급류체저벽면절응력면적비(LSA)、류체전절진탕지수(OSI)등혈류동역학지표상차이무통계학의의,이파렬전기조평균류체벽면절응력(WSS)교파렬조현저강저(P=0.024);기중경체비(AR)여LSA화OSI존재정상관관계,체경비(SR)여평균류체WSS존재부상관관계.결론 처우파렬전기적로내동맥류여파렬로내동맥류유착상사형태학급혈류동역학특정,교저적WSS화자낭적형성가능시촉진동맥류파렬적중요인소.
Objective To identify the significant morphologic and hemodynamic parameters in per -ruptured period and assess the risk factors of intracranial aneurysms.Methods The CFD model was constructed from patient-specific 3D rotation angiographic images.Three-cardiac-cycle simulation was performed and the morphologic and hemodynamic parameters in the second cardiac cycle were calculated and analyzed in the pre-ruptured and ruptured group.Results There was no significant statistical difference between two groups in the morphologic parameters.The Hemodynamic parameter significantly different between the two groups was the WSS of aneurysm wall (P =0.024).For pre-ruptured group,there was a statistically significant correlation between AR and LSA (rs =0.833,P =0.005),AR and OSI (rs =0.817,P =0.007),SR and WSS of aneurysm wall (rs =-0.683,P =0.042) ; for ruptured group,there was no significant correlation established.Conclusions The "pre-ruptured" aneurysms had similar morphologic and hemodynamic characteristics compared with the ruptured ones.Low WSS and bleb formation might play an important role in aneurysm rupture.