CAJ | 학술논문

目的分析缺血性脑卒中(IS)发生的危险因素,探讨C-反应蛋白(CRP)基因中rs1130864位点与IS的相关性. 方法选取滨州医学院附属医院神经内科自2010年12月至2011年12月收治的128例IS患者作为病例组,同期无动脉粥样硬化血管病史的门诊体检者112例作为对照组,采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)检测2组受试者rs1130864位点的基因型；Logistic多元回归分析方法分析IS的危险因素. 结果病例组中男性患者比例、高血压病史、糖尿病史、高血脂病史、吸烟史、饮酒史和家族脑卒中史的发生率均明显高于对照组,差异有统计学意义(P＜0.05)；2组rs1130864位点基因型、等位基因频率及显性模型比较差异无统计学意义(P＞0.05),但隐性模型比较差异有统计学意义(P＜0.05); Logistic回归分析显示男性、高血压病史、糖尿病史、吸烟史及rs1130864的隐性模型(TT+CT)是IS发生的独立危险因素. 结论男性、高血压病史、糖尿病史、吸烟史及rsl 130864的隐性模型(TT+CT)是IS发生的独立危险因素.
목적 분석결혈성뇌졸중(IS)발생적위험인소,탐토C-반응단백(CRP)기인중rs1130864위점여IS적상관성. 방법 선취빈주의학원부속의원신경내과자2010년12월지2011년12월수치적128례IS환자작위병례조,동기무동맥죽양경화혈관병사적문진체검자112례작위대조조,채용한제성편단장도다태성취합매련반응(PCR-RFLP)검측2조수시자rs1130864위점적기인형；Logistic다원회귀분석방법분석IS적위험인소. 결과 병례조중남성환자비례、고혈압병사、당뇨병사、고혈지병사、흡연사、음주사화가족뇌졸중사적발생솔균명현고우대조조,차이유통계학의의(P＜0.05)；2조rs1130864위점기인형、등위기인빈솔급현성모형비교차이무통계학의의(P＞0.05),단은성모형비교차이유통계학의의(P＜0.05); Logistic회귀분석현시남성、고혈압병사、당뇨병사、흡연사급rs1130864적은성모형(TT+CT)시IS발생적독립위험인소. 결론 남성、고혈압병사、당뇨병사、흡연사급rsl 130864적은성모형(TT+CT)시IS발생적독립위험인소.
Objective To investigate the association between the rs1130864 polymorphisms in C-reactive protein (CRP) gene and ischemic stroke (IS).Methods One hundred and twenty-eight patients with IS,admitted to our hospital from December 2010 to December 2011,another 112 healthy subjects without atherosclerotic vascular disease history were chosen in our study.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the genotype ofrs1130864 site.Logistic multivariate regression analysis was employed to analyze the IS risk factors.Results The ratio of male patients,having history of hypertension,diabetes,hyperlipidemia,smoking and familial stroke in the patient group was significantly higher than that in control group (P＜0.05).The allele frequency,genotype and dominant model of rs1130864 site showed no statistically significant difference between the 2 groups (P＞0.05),but the recessive model ofrs1130864 site showed significant difference between the 2 groups (P＜0.05).Logistic regression analysis showed that male and having history of hypertension,diabetes and smoking in patients with rs1130864 recessive model (TT+CT) are the independent risk factors for IS (P＜0.05).Conclusion Male and history of hypertension,diabetes and smoking history in patients with rs1130864 recessive model (TT+CT) are independent risk factor for IS.