CAJ | 학술논문

目的观察促红细胞生成素(EPO)对颅内动脉瘤术后脑缺血患者的治疗作用. 方法选择自2006年5月至2010年8月在山东省聊城市人民医院神经外科行颅内动脉瘤手术,且术后发现脑缺血的60例患者,按照随机数字表法分为对照组和治疗组,每组30例.治疗组在常规治疗基础上给予EPO皮下注射,剂量为3000IU,连用3d.对照组在常规治疗基础上给予同等剂量生理盐水治疗.利用美国国立卫生研究院卒中量表(NIHSS)对2组患者入院当天、EPO/生理盐水治疗后1、2、3、4、5周各进行一次评分.利用MRI弥散加权成像(DWI)测定缺血当天及缺血后1、2、3、4、5周时2组患者脑缺血面积. 结果治疗第3、4、5周时,治疗组与对照组NIHSS评分分别为(9.4±1.9)vs(11.3±2.3)、(8.7±1.7)vs(10.8±2.2)、(7.9±1.6)vs(10.1±2.3),差异有统计学意义(P＜0.05).同时,治疗第3、4、5周,治疗组与对照组脑缺血面积缩小百分率的差异也有统计学意义(P＜0.05),具体值分别为(21.6±4.1)％vs(16.8±3.1)％、(27.5±5.3)％vs(18.9±3.3)％、(32.8±5.5)％vs(19.5±3.4)％. 结论 EPO能够通过促进缺血脑组织微循环重建的机制起到神经保护作用.
목적 관찰촉홍세포생성소(EPO)대로내동맥류술후뇌결혈환자적치료작용. 방법 선택자2006년5월지2010년8월재산동성료성시인민의원신경외과행로내동맥류수술,차술후발현뇌결혈적60례환자,안조수궤수자표법분위대조조화치료조,매조30례.치료조재상규치료기출상급여EPO피하주사,제량위3000IU,련용3d.대조조재상규치료기출상급여동등제량생리염수치료.이용미국국립위생연구원졸중량표(NIHSS)대2조환자입원당천、EPO/생리염수치료후1、2、3、4、5주각진행일차평분.이용MRI미산가권성상(DWI)측정결혈당천급결혈후1、2、3、4、5주시2조환자뇌결혈면적. 결과 치료제3、4、5주시,치료조여대조조NIHSS평분분별위(9.4±1.9)vs(11.3±2.3)、(8.7±1.7)vs(10.8±2.2)、(7.9±1.6)vs(10.1±2.3),차이유통계학의의(P＜0.05).동시,치료제3、4、5주,치료조여대조조뇌결혈면적축소백분솔적차이야유통계학의의(P＜0.05),구체치분별위(21.6±4.1)％vs(16.8±3.1)％、(27.5±5.3)％vs(18.9±3.3)％、(32.8±5.5)％vs(19.5±3.4)％. 결론 EPO능구통과촉진결혈뇌조직미순배중건적궤제기도신경보호작용.
Objective To investigate the efficacy of erythropoietin (EPO) on cerebral ischemia of patients after intracranial aneurysm surgery.Methods Sixty patients with cerebral ischemia after operation of intracranial aneurysm,admitted to our hospital from May 2006 to August 2010,were randomly divided into control and treatment groups (n=30).Control group received conventional treatment,while the other group,on the basis of conventional therapy,was hypodermically given EPO at a dosage of 3000 IU for a consecutive 3 days.U.S.National Institutes of Health Stroke Scale (NIHSS) was used to score the patients on the admission day,1,2,3,4 and 5 weeks after EPO treatment; and diffusion-weighted imaging (DWI) of MRI was used in determining the changes of cerebral ischemic area on the ischemic day and l,2,3,4 and 5 weeks after ischemic.Results NIHSS scores of the EPO group (9.4±1.9,11.3±2.3,8.7±1.7) at 3,4 and 5 weeks after treatment were significantly higher as compared with those in the control group (10.8±2.2,7.9±1.6,10.1±2.3) (P＜0.05).Similarly,3,4 and 5 weeks after treatment,the reducing percentage of cerebral ischemia area in the EPO group (21.6±4.1,27.5±5.3,32.8±5.5)％ was larger than that in the control group (16.8±3.1,18.9±3.3,19.5±3.4)％ (P＜0.05).Conclusion EPO may play an effective role in cerebral ischemia of patients after intracranial aneurysm operation.