CAJ | 학술논문

目的探讨颅咽管瘤中白介素1α(IL-1α)、白介素6(IL-6)的表达与其病理类型、手术切除率及术后复发率的关联性及其临床意义. 方法选取中山大学附属第一医院神经外科自2003年1月至2009年10月行显微外科手术切除的颅咽管瘤肿瘤标本69例,其中釉质细胞型52例,乳头鳞状细胞型17例,免疫组织化学染色检测肿瘤组织中IL-1α、IL-6的表达,分析IL-1α、IL-6表达与肿瘤病理类型、手术全切除率、术后复发率的关系. 结果本组肿瘤全切除50例,次全切除13例,大部分切除6例；随访患者64例,复发9例(14.1％)；免疫组化检测显示28例标本IL-6表达阳性,3例IL-1α表达阳性;不同病理类型、术后是否复发肿瘤中IL-1α、IL-6的阳性表达率比较差异均无统计学意义(P＞0.05)；是否全切肿瘤中IL-1α阳性表达率比较差异无统计学意义(P＞0.05),而IL-6的阳性表达率比较差异有统计学意义(P＜0.05). 结论 IL-6参与了颅咽管瘤与周围脑组织的炎症反应,这种炎症反应可能是颅咽管瘤手术难以全切除的一个重要影响因素.
목적 탐토로인관류중백개소1α(IL-1α)、백개소6(IL-6)적표체여기병리류형、수술절제솔급술후복발솔적관련성급기림상의의. 방법 선취중산대학부속제일의원신경외과자2003년1월지2009년10월행현미외과수술절제적로인관류종류표본69례,기중유질세포형52례,유두린상세포형17례,면역조직화학염색검측종류조직중IL-1α、IL-6적표체,분석IL-1α、IL-6표체여종류병리류형、수술전절제솔、술후복발솔적관계. 결과 본조종류전절제50례,차전절제13례,대부분절제6례；수방환자64례,복발9례(14.1％)；면역조화검측현시28례표본IL-6표체양성,3례IL-1α표체양성;불동병리류형、술후시부복발종류중IL-1α、IL-6적양성표체솔비교차이균무통계학의의(P＞0.05)；시부전절종류중IL-1α양성표체솔비교차이무통계학의의(P＞0.05),이IL-6적양성표체솔비교차이유통계학의의(P＜0.05). 결론 IL-6삼여료로인관류여주위뇌조직적염증반응,저충염증반응가능시로인관류수술난이전절제적일개중요영향인소.
Objective To investigate the correlations of interleukin-1α (IL-1α) and IL-6expressions in craniopharyngiomas with the pathological subtypes,removal rate and recurrence rate,and explore their clinical significance.Methods Sixty-nine pathologic specimens ofcraniopharyngiomas,collected in our hospital during the microsurgery from January 2003 to October 2009,were chosen in our study; the craniopharyngiomas were classified into two different pathological subtypes:enamel cells and nipple squamous cells.The IL-1α and IL-6 expressions were detected in craniopharyngioma tissues by immunohistochemistry.The correlations of IL-1α and IL-6 expressions in craniopharyngiomas with the pathological subtypes,removal rate and recurrence rate were analyzed statistically.Results The total tumor removal was achieved in 50 cases (72.5％),subtotal removal in 13 cases (18.8％) and partial removal in 6 cases (8.7％).Nine cases (14.1％) were recurrent during the follow-up.IL-6-positive expression was detected in 28 cases,and IL-1α-positive expression in 3 cases; IL-1α and IL-6 expressions in craniopharyngiomas with different pathological subtypes showed no significant difference (P＞0.05);craniopharyngiomas with postoperative recurrence or without showed no obvious difference (P＞0.05).The difference of IL-1 α expression in patients with total removal,subtotal removal and partial removal showed no statistically significance (P＞0.05); while that of IL-6 expression had significant difference (P＜0.05).Conclusion IL-6 involves in the inflammatory reaction between craniopharyngioma and its surrounding brain tissues,which may be the important influencing factor of total removal of the craniopharyngioma.