CAJ | 학술논문

目的利用功能磁共振成像(fMRI)技术探讨静息状态下腰背痛患者脑局部一致性(ReHo)变化的特点. 方法选择自2011年8月至2012年1月南方医科大学珠江医院康复医学科招募的15例年龄、性别和文化程度相近的健康者作为受试者,向其右侧腰背部肌肉注射0.3 mL30g/L的高渗盐水制造腰背痛模型,采用3.0T MR仪分别在注射前、注射后进行静息状态fMRI扫描,所得数据进行配对t检验,比较疼痛及非疼痛状态下静息态脑功能的局部一致性差异. 结果与正常状态相比,腰背痛受试者ReHo增高的脑区有:双侧前额叶内侧、左额下回、右额中回、右小脑扁桃体、右脑桥、右岛叶、右尾状核、右楔前叶、右海马旁回、后扣带回；ReHo减低的脑区有:右颞上回、左颞中回、左中央前回、左中央后回、左海马旁回、左梭状回、左前扣带回、左顶上小叶、右顶下小叶(P＜0.005,体素值≥10). 结论静息状态下腰背痛患者部分脑区存在脑活动区域一致性异常.
목적 이용공능자공진성상(fMRI)기술탐토정식상태하요배통환자뇌국부일치성(ReHo)변화적특점. 방법 선택자2011년8월지2012년1월남방의과대학주강의원강복의학과초모적15례년령、성별화문화정도상근적건강자작위수시자,향기우측요배부기육주사0.3 mL30g/L적고삼염수제조요배통모형,채용3.0T MR의분별재주사전、주사후진행정식상태fMRI소묘,소득수거진행배대t검험,비교동통급비동통상태하정식태뇌공능적국부일치성차이. 결과 여정상상태상비,요배통수시자ReHo증고적뇌구유:쌍측전액협내측、좌액하회、우액중회、우소뇌편도체、우뇌교、우도협、우미상핵、우설전협、우해마방회、후구대회；ReHo감저적뇌구유:우섭상회、좌섭중회、좌중앙전회、좌중앙후회、좌해마방회、좌사상회、좌전구대회、좌정상소협、우정하소협(P＜0.005,체소치≥10). 결론 정식상태하요배통환자부분뇌구존재뇌활동구역일치성이상.
Objective To explore the characteristics of the brain regional homogeneity (ReHo)alterations in patients with low back pain disorders using resting-state functianal magnetic resonance imaging (fMRI).Methods Resting-sate fMRI 3.0T scans were separately performed on 15 age-and gender-matched healthy subjects at rest as baseline and during pain of the back muscle (intramuscular injection of 3 g/L hypertonic saline).The ReHo maps were analyzed with paired t-test to compare the changes between the pain and healthy status.Results As compared with the health subjects,the subjects with low back pain showed significantly increased ReHo levels in the bilateral medial prefrontal cortex (mPFC),left inferior frontal gyrus,right middle frontal gyrus,cerebellum posterior lobe-cerebellar tonsil,right pons,fight insula,right caudate,right precuneus,fight parahippocampa gyrus and posterior cingulate gyrus,and decreased ReHo levels in the right superior temporal gyrus,left middle temporal gyrus,left precentral gyrus,left postcentral gyrus,left parahippocampa gyrus,left fusiform gyrus,left anterior cingulate,left superior parietal lobule,right inferior parietal lobule (P＜0.005,cluster threshold ≥10).Consulsion People with low back pain show abnormal spontaneous activity in certain brain regions.