中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2013年
6期
621-624
,共4页
周振军%孙新林%文平%柯以铨
週振軍%孫新林%文平%柯以銓
주진군%손신림%문평%가이전
颅内感染%降钙素原%白细胞计数%脑脊液
顱內感染%降鈣素原%白細胞計數%腦脊液
로내감염%강개소원%백세포계수%뇌척액
Intracranial infection%Procalcitonin%White blood cell count%Cerebrospinal fluid
目的 研究降钙素原(PCT)水平在开颅术后颅内感染诊断中的价值. 方法 收集开颅术后颅内感染患者(n=20)和非颅内感染患者(n=20)的脑脊液和血液样本,检测脑脊液和血清PCT,脑脊液和血液白细胞计数等指标并进行统计分析. 结果 感染组脑脊液和血清PCT水平、脑脊液白细胞计数较非感染组显著升高,差异有统计学意义(P<0.05).脑脊液PCT和白细胞计数诊断敏感性较高(95%、90%),脑脊液和血清PCT诊断特异性较高(90%、80%).脑脊液PCT和脑脊液白细胞计数及血清PCT呈显著正相关(r=0.729,P=0.000;r=0.679,P=0.000). 结论 脑脊液PCT、脑脊液白细胞计数和血清PCT在颅脑手术术后颅内感染的诊断中均有意义,其中脑脊液PCT较脑脊液白细胞计数误诊率更低,较血清PCT敏感性更高,临床应用价值更大.
目的 研究降鈣素原(PCT)水平在開顱術後顱內感染診斷中的價值. 方法 收集開顱術後顱內感染患者(n=20)和非顱內感染患者(n=20)的腦脊液和血液樣本,檢測腦脊液和血清PCT,腦脊液和血液白細胞計數等指標併進行統計分析. 結果 感染組腦脊液和血清PCT水平、腦脊液白細胞計數較非感染組顯著升高,差異有統計學意義(P<0.05).腦脊液PCT和白細胞計數診斷敏感性較高(95%、90%),腦脊液和血清PCT診斷特異性較高(90%、80%).腦脊液PCT和腦脊液白細胞計數及血清PCT呈顯著正相關(r=0.729,P=0.000;r=0.679,P=0.000). 結論 腦脊液PCT、腦脊液白細胞計數和血清PCT在顱腦手術術後顱內感染的診斷中均有意義,其中腦脊液PCT較腦脊液白細胞計數誤診率更低,較血清PCT敏感性更高,臨床應用價值更大.
목적 연구강개소원(PCT)수평재개로술후로내감염진단중적개치. 방법 수집개로술후로내감염환자(n=20)화비로내감염환자(n=20)적뇌척액화혈액양본,검측뇌척액화혈청PCT,뇌척액화혈액백세포계수등지표병진행통계분석. 결과 감염조뇌척액화혈청PCT수평、뇌척액백세포계수교비감염조현저승고,차이유통계학의의(P<0.05).뇌척액PCT화백세포계수진단민감성교고(95%、90%),뇌척액화혈청PCT진단특이성교고(90%、80%).뇌척액PCT화뇌척액백세포계수급혈청PCT정현저정상관(r=0.729,P=0.000;r=0.679,P=0.000). 결론 뇌척액PCT、뇌척액백세포계수화혈청PCT재로뇌수술술후로내감염적진단중균유의의,기중뇌척액PCT교뇌척액백세포계수오진솔경저,교혈청PCT민감성경고,림상응용개치경대.
Objective To explore the diagnostic value of cerebrospinal fluid procalcitonin (PCT) level in intracranial infection after craniotomy.Methods Forty post-craniotomy patients with suspicious intracranial infection were chosen in our study; these patients were divided into infected and disinfected group (n=20).PCT and white blood cell (WBC) counts in the serum and cerebrospinal fluid were detected and analyzed,respectively.Results Both PCT and WBC values in the cerebrospinal fluid and serum in the infected group were significantly higher than those in the disinfected group (P<0.05).Both PCT and WBC in the CSF had good sensitivity,and PCT in the cerebrospinal fluid and serum had high specificity.Correlation analysis indicated that CSF WBC and serum PCT were positively correlated to CSF PCT (r=0.729,P=0.000; r=0.679,P=0.000).Conclusion CSF PCT could be proposed as an effective diagnostic marker for intracranial infection and it is superior to serum PCT and WBC count.