中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2013年
12期
1205-1208
,共4页
刘焕光%张建国%张凯%孟凡刚%杨岸超%孟大伟
劉煥光%張建國%張凱%孟凡剛%楊岸超%孟大偉
류환광%장건국%장개%맹범강%양안초%맹대위
脑深部电刺激%脚桥核%丘脑底核%帕金森病
腦深部電刺激%腳橋覈%丘腦底覈%帕金森病
뇌심부전자격%각교핵%구뇌저핵%파금삼병
Deep brain stimulation%Pedunculopontine nucleus%Subthalamic nucleus%Parkinson's disease
目的 初步探讨脚桥核(PPN)脑深部电刺激(DBS)治疗帕金森病(PD)的疗效. 方法 天坛医院神经外科2010年8月10日对1例PD患者进行PPN-DBS治疗,患者治疗前分别接受双侧PPN和丘脑底核(STN)试验性刺激,利用统一帕金森病评分量表(UPDRS)评分、冻结步态问卷、姿势及摔倒问卷评价两者疗效差异.随访1年,同样采用上述评分及问卷评价PPN-DBS治疗效果.结果 PPN-DBS可以有效缓解该患者的冻结步态、运动迟缓等主要症状,而STN-DBS虽然能够改善患者运动功能,但是对冻结步态等缓解不明显.患者最终接受PPN-DBS治疗.随访1年间,运动及步态评分均有显著改善,但是随着随访期的延长,缓解作用有减弱的趋势. 结论 PPN-DBS对于缓解冻结步态、运动迟缓等PD症状具有较好的疗效.
目的 初步探討腳橋覈(PPN)腦深部電刺激(DBS)治療帕金森病(PD)的療效. 方法 天罈醫院神經外科2010年8月10日對1例PD患者進行PPN-DBS治療,患者治療前分彆接受雙側PPN和丘腦底覈(STN)試驗性刺激,利用統一帕金森病評分量錶(UPDRS)評分、凍結步態問捲、姿勢及摔倒問捲評價兩者療效差異.隨訪1年,同樣採用上述評分及問捲評價PPN-DBS治療效果.結果 PPN-DBS可以有效緩解該患者的凍結步態、運動遲緩等主要癥狀,而STN-DBS雖然能夠改善患者運動功能,但是對凍結步態等緩解不明顯.患者最終接受PPN-DBS治療.隨訪1年間,運動及步態評分均有顯著改善,但是隨著隨訪期的延長,緩解作用有減弱的趨勢. 結論 PPN-DBS對于緩解凍結步態、運動遲緩等PD癥狀具有較好的療效.
목적 초보탐토각교핵(PPN)뇌심부전자격(DBS)치료파금삼병(PD)적료효. 방법 천단의원신경외과2010년8월10일대1례PD환자진행PPN-DBS치료,환자치료전분별접수쌍측PPN화구뇌저핵(STN)시험성자격,이용통일파금삼병평분량표(UPDRS)평분、동결보태문권、자세급솔도문권평개량자료효차이.수방1년,동양채용상술평분급문권평개PPN-DBS치료효과.결과 PPN-DBS가이유효완해해환자적동결보태、운동지완등주요증상,이STN-DBS수연능구개선환자운동공능,단시대동결보태등완해불명현.환자최종접수PPN-DBS치료.수방1년간,운동급보태평분균유현저개선,단시수착수방기적연장,완해작용유감약적추세. 결론 PPN-DBS대우완해동결보태、운동지완등PD증상구유교호적료효.
Objective To explore the treatment efficacy of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) in a patient with Parkinson's disease (PD).Methods The patient,admitted to our hospital in August 10,2010,was chosen in the study; in the first stage of surgery,PPN and STN stimulation tests were performed; Unified Parkinson's disease rating scale,freezing gait questionnaire,and posture and fall assessment questionnaire were employed to compare the treatment efficacy.According to these results,PPN-DBS was performed in the patient in the second stage of surgery,and the above the rating scale,questionnaires were also performed to compare the treatment efficacy.Results PPN-DBS provided modest improvements in the gait disorder and freezing episodes,while STN-DBS failed to improve the dominant problems.The patient accepted PPN-DBS treatment with obvious improvement in movement and gait; with the follow-up being prolonged,the alleviation trend was weakening.Conclusion PPN-DBS may have a unique role in ameliorating frozen gait,bradykinesia and other symptoms of PD.