中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2014年
4期
325-328
,共4页
自噬%脓毒症%肺损伤%治疗靶点
自噬%膿毒癥%肺損傷%治療靶點
자서%농독증%폐손상%치료파점
Autophagy%Sepsis%Lung injury%Therapeutic targets
Sepsis is one of the most common pathogenetic causes of acute lung injury (ALI),and at present there is still a lack of effective targeted techniques and methods for its prevention and treatment.Autophagy is a homeostatic mechanism common to all eukaryotic cells,including adaption to environment,defense against invasion of pathogens,and maintenance of cellular homeostasis.Autophagy is also involved in a variety of lung-related diseases.In septic lung injury,autophagy not only serves to dissipate dysfunctional organelles,but also inhibits the release of inflammatory cytokines.This review aims at eliciting the role of autophagy in sepsis-induced ALI and further exploring the potential targets of autophagy in inhibiting inflammation,in an effort to provide a new perspective for clinical treatment of sepsis-induced ALI.
