CAJ | 학술논문

目的了解唇鳞状细胞癌患者人乳头瘤病毒感染的情况.方法对收集到的9例临床诊断唇癌病例的石蜡组织标本应用Luminex及PCR的方法对HPV感染进行基因检测,应用免疫组织化学的方法对HPV16/18E6蛋白进行检测.结果在9例临床诊断的唇癌病例中,通过Luminex 及PCR的方法发现1例病例具有HPV16的感染;通过免疫组织化学的方法发现7例病例具有HPV16/18的感染,总阳性率达到8/9.结论此研究中在唇癌患者中较高的HPV感染率间接说明皮肤的直接接触对HPV感染的重要性,为阐明唇癌的发病机制提供依据.
목적 료해진린상세포암환자인유두류병독감염적정황.방법 대수집도적9례림상진단진암병례적석사조직표본응용Luminex급PCR적방법대HPV감염진행기인검측,응용면역조직화학적방법대HPV16/18E6단백진행검측.결과 재9례림상진단적진암병례중,통과Luminex 급PCR적방법발현1례병례구유HPV16적감염;통과면역조직화학적방법발현7례병례구유HPV16/18적감염,총양성솔체도8/9.결론 차연구중재진암환자중교고적HPV감염솔간접설명피부적직접접촉대HPV감염적중요성,위천명진암적발병궤제제공의거.
Objective To analyze the infection of human papillomavirus in lip squamous cell carcinoma patients.Methods The pathological samples of 9 clinical diagnosed lip cancer patients were collected.Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.Results In the 9 cases,1 was positive for HPV16 gene and 7 were positive for HPV16/18 E6 protein expression.The total positive rate was about 8/9.Conclusion The high HPV infection rate in lip cancer patients in the study indicated indirectly that the importance of the direct contact to the infection of HPV what was the basis for pathogenesis of the lip squamous cell carcinoma.