CAJ | 학술논문

目的了解徐州市2005-2011年度流感流行状况、流感病毒流行株构成,为流感预防控制工作提供科学的依据.方法对2005-2011年国家级流感样病例监测哨点医院采集的流感样病例咽拭子标本,按照《全国流感监测方案》和《流行性感冒病毒及其实验技术》要求,进行流感病毒分离及初步鉴定后,上送国家流感中心进行复核.结果 2005年10月至2011年12月共采集流感样病例标本9561份,分离流感毒株1152株,总分离率为12.0％.其中A型708株(61.5％)、B型444株(38.5％)；分离流感病毒各亚型构成比A1(HlNI)为14.2％(164株)、A3(H3 N2)为40.5％(466株)、新HINI 6.8％(78株)；BV(Victoia) 31.4％(362株)、BY(Yamagate) 7.1％(82株).2007年检出率最高为25.9％(214/826),其次是2009年为17.4％(471/2708),2011年检出率最低为2.3％(38/1681).2005-2006年冬春季,以A1(H1N1)亚型为主要流行株；2006年冬季,转为以BV为优势株；2007-2009年夏季,一直以A3 (H3N2)为流行优势株,期间的2008年A1(H1N1)、A3(H3N2)、BV、BY四种亚型并存流行；2009年冬季以新H1N1亚型和BV为优势株；2010-2011年,以BV为流行优势株.A3(H3N2)感染在全年均有发生,但在冬季和夏季有两个显著的感染高峰,BV亚型在冬春夏季均有检出,主要感染高峰在冬春季.流感病毒分离率最高为1月份(34.4％),分离率最低为7月份(2.2％).各年龄组人群均分离出流感病毒,其中5 ～年龄组分离率(24.0％)最高,25～年龄组分离最低.结论徐州市2005-2011年以来,先后以流感病毒A1(H1N1)、A3(H3N2)、新H1N1、BV 亚型交替为主要流行优势株,其中BV亚型在人群中的流行显示逐年增强.
목적 료해서주시2005-2011년도류감류행상황、류감병독류행주구성,위류감예방공제공작제공과학적의거.방법 대2005-2011년국가급류감양병례감측초점의원채집적류감양병례인식자표본,안조《전국류감감측방안》화《류행성감모병독급기실험기술》요구,진행류감병독분리급초보감정후,상송국가류감중심진행복핵.결과 2005년10월지2011년12월공채집류감양병례표본9561빈,분리류감독주1152주,총분리솔위12.0％.기중A형708주(61.5％)、B형444주(38.5％)；분리류감병독각아형구성비A1(HlNI)위14.2％(164주)、A3(H3 N2)위40.5％(466주)、신HINI 6.8％(78주)；BV(Victoia) 31.4％(362주)、BY(Yamagate) 7.1％(82주).2007년검출솔최고위25.9％(214/826),기차시2009년위17.4％(471/2708),2011년검출솔최저위2.3％(38/1681).2005-2006년동춘계,이A1(H1N1)아형위주요류행주；2006년동계,전위이BV위우세주；2007-2009년하계,일직이A3 (H3N2)위류행우세주,기간적2008년A1(H1N1)、A3(H3N2)、BV、BY사충아형병존류행；2009년동계이신H1N1아형화BV위우세주；2010-2011년,이BV위류행우세주.A3(H3N2)감염재전년균유발생,단재동계화하계유량개현저적감염고봉,BV아형재동춘하계균유검출,주요감염고봉재동춘계.류감병독분리솔최고위1월빈(34.4％),분리솔최저위7월빈(2.2％).각년령조인군균분리출류감병독,기중5 ～년령조분리솔(24.0％)최고,25～년령조분리최저.결론 서주시2005-2011년이래,선후이류감병독A1(H1N1)、A3(H3N2)、신H1N1、BV 아형교체위주요류행우세주,기중BV아형재인군중적류행현시축년증강.
Objective To investigate the prevalence and subtypes of influenza viruses in Xuzhou city from 2005 to 2011 and to provide the scientific supports for influenza prevention and control in this religion.Methods The throat swab samples were collected from the influenza-like cases from national influenza like illness sentinel hospital in Xuzhou.The samples were used for influenza virus isolation and identification,sent on the national flu center to confirm according to the " national influenza surveillance program" and "influenza virus and experimental technology".Results From Oct.2005 to Dec.2011,a total of 9561 swab specimens were collected in which 1152 strains were identified for influenza viruses with total isolated rate of 12.0％.Among these strains,708 strains were A1 (H1N1) subtype(14.2％),466 strains were A3 (H3N2) subtype(40.5％),78 strains were new H1N1 subtype(6.8％),362 strains wereBV(Victoia) subtype (31.4％) and 82 strains were BY (Yamagate) subtype (7.1％).The top detection rate (25.9％) arose in 2007,secondary detection rate (17.4％) occurred at 2009 and the lowest one (2.3％) appeared in 2011.From the winter of 2005 to the spring of 2006 A1 (H1N1) subtype had appeared as predominant strains but in the winter of 2006 the predominant strains were BV subtype.It changed to A3 subtype in 2007 to 2009 and the other three dominant strains were A1,BV and BY in 2008.In the winter of 2009,both A3 (H3N2) and new H1N1 subtype were predominant strains.BV subtype was predominant strains in 2010 to 2011.The prevalence of A3 subtype appeared in all the year while prevalence of BV only arose in the spring and winter.So the detection rate was high in January (34.4％) but low in August (2.2％).The influenza population is correlated with age,the highest detection rate arose in 5-age group and the lowest detection rate appeared in 25-age group.Conclusion Influenza subtype A1,A3,New H1N1 are all appeared as predominant strains in Xuzhou city from 2005 to 2010.Besides,the prevalence of BV subtype is stronger in recently.