2008-2010年C4a人肠道病毒71型在中国大陆的广泛传播和流行
2008-2010년C4a인장도병독71형재중국대륙적엄범전파화류행
Transmission and prevalence patterns of C4a evolutionary lineage of human enterovirus 71 circulating in mainland of China, 2008-2010
  • 万方数据
    中华实验和临床病毒学杂志 중화실험화림상병독학잡지
    CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
    2012年 6期 425-428 ,共4页

    石晶%张燕%周剑惠%朱贞%毛乃颖%许松涛%崔爱利%檀晓娟%祝双利%张勇%严冬梅%孔晓慧%许文波

    석정%장연%주검혜%주정%모내영%허송도%최애리%단효연%축쌍리%장용%엄동매%공효혜%허문파

    肠道病毒属%种系发生%疾病传播 腸道病毒屬%種繫髮生%疾病傳播
    장도병독속%충계발생%질병전파
    Enterovirus%Phylogeny%Disease transmission
    目的 了解2008-2010年流行于中国大陆的人肠道病毒71型(human enterovirus 71,HEV71)病毒和2008年安徽阜阳株的进化关系以及C4a进化分支病毒在中国大陆各省、区的传播和流行情况.方法 从GenBank上获得2008-2010年中国大陆各省份流行的具有完整VP1(≥891bp)或近似完整VP1(≥876 bp)基因的核苷酸序列信息的HEV71毒株序列,采用MEGA 5.0软件,构建种系发生树,分析2008-2010年流行于中国大陆各省、区的C4a HEV71病毒与安徽阜阳株间的分子流行病学关系.结果 中国大陆2008-2010年流行的HEV71分离株除了8株属于A型,一株属于进化分支C4b外,其他均为C4a；目前流行于中国大陆各省、区的C4a病毒与2008年安徽阜阳株同源性较高(96.5％～100％),其溯源可至1998年的C4b病毒.2008年的阜阳株所引发的传播链主要集中在广东、江苏、上海、湖南、山东等省市.结论 中国大陆2008-2010年流行的HEV71分离株以C4a进化分支病毒为绝对优势病毒,阜阳株传播链主要分布在中国南部和以安徽为中心的中原地区.
    목적 료해2008-2010년류행우중국대륙적인장도병독71형(human enterovirus 71,HEV71)병독화2008년안휘부양주적진화관계이급C4a진화분지병독재중국대륙각성、구적전파화류행정황.방법 종GenBank상획득2008-2010년중국대륙각성빈류행적구유완정VP1(≥891bp)혹근사완정VP1(≥876 bp)기인적핵감산서렬신식적HEV71독주서렬,채용MEGA 5.0연건,구건충계발생수,분석2008-2010년류행우중국대륙각성、구적C4a HEV71병독여안휘부양주간적분자류행병학관계.결과 중국대륙2008-2010년류행적HEV71분리주제료8주속우A형,일주속우진화분지C4b외,기타균위C4a；목전류행우중국대륙각성、구적C4a병독여2008년안휘부양주동원성교고(96.5％～100％),기소원가지1998년적C4b병독.2008년적부양주소인발적전파련주요집중재엄동、강소、상해、호남、산동등성시.결론 중국대륙2008-2010년류행적HEV71분리주이C4a진화분지병독위절대우세병독,부양주전파련주요분포재중국남부화이안휘위중심적중원지구.
    Objective To understand the evolutionary relationship between the C4a evolutionary lineage of human enterovirus 71 (HEV71) strains circulating in mainland of China during 2008-2010 and 2008 Fuyang strains and study the prevalence and transmission patterns of 2008 Fuyang strains.Methods Download all the complete VP1 (≥ 891 bp) or approximate complete VP1 (≥ 876 bp) gene nucleotide sequences from GenBank of HEV71 strains circulating in Mainland of China during 2008-2010.And analyze the phylogenetic relationship between Fuyang strains and other provinces' strains using the MEGA software,version 5.0.Results All of the HEV71 isolates circulating in Mainland of China during 2008-2010 were clustered into evolutionary lineage C4a except for eight strains grouped in the genotype A and one isolate belongs to evolutionary lineage C4b; the homology analysis showed there were 96.5％-100％ identity between C4a viruses circulating in mainland China during 2008-2010 and 2008 Fuyang strains,and they were evolved from C4b viruses of 1998.The transmission chains of Fuyang strains were mainly transmitted in Guangdong,Jiangsu,Shanghai,Hunan,Shandong provinces.Conclusion The predominant viruses circulating in Mainland of China during 2008-2010 were evolutionary lineage C4a of human Enterovirus 71 ;Fuyang transmission chains mainly distributed in southern of China and the Central China around Anhui provinces.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문