中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2013年
4期
244-246
,共3页
魏红山%康艳芳%郝晓花%刘佳%李红敏%刘爱霞%任慧%黄玉波%李伯安
魏紅山%康豔芳%郝曉花%劉佳%李紅敏%劉愛霞%任慧%黃玉波%李伯安
위홍산%강염방%학효화%류가%리홍민%류애하%임혜%황옥파%리백안
高尔基体%脂肪肝%肝炎%生物学标记
高爾基體%脂肪肝%肝炎%生物學標記
고이기체%지방간%간염%생물학표기
Golgi apparatus%Fatty liver%Hepatitis%Biologic markers
目的 观察不同病因肝细胞脂肪变对肝病患者血清GP73水平的影响.方法 以100例健康体检者为对照,观察178例肝穿刺病理学检查发现肝脂肪变性患者的血清GP73水平差异.结果 与健康对照人群(35.61±12.22 ng/ml)相比,不同病因导致的脂肪肝患者(70.62±60.60 ng/ml)血清GP73显著升高.尽管酒精性脂肪肝(81.86±47.82 ng/ml)和急性肝损伤患者合并肝细胞脂肪变(82.77±77.73 ng/ml)血清GP73水平略高于慢性乙型肝炎患者(63.84±50.62 ng/ml)和非酒精脂肪肝患者(65.75±62.20 ng/ml),但不同病因导致的肝细胞脂肪变并未显示血清GP73水平差异有统计学意义.更为重要的是,68例F≥1.0(71.46 ±66.48 ng/ml),75例F≥2.0(69.58±62.31ng/ml),以及34例F3-F4的患者(71.65±43.89 ng/ml),血清GP73的水平差异无统计学意义(F=0.02,P=0.98).相反,显著性肝纤维化S≥2患者(91.04±82.37 ng/ml)其血清GP73水平显著高于纤维化轻微S ＜2(65.80±53.45 ng/ml)的患者(P =0.029).结论 肝细胞脂肪变导致血清GP73水平显著升高,但肝细胞脂肪变的程度似乎与血清GP73水平无关.
目的 觀察不同病因肝細胞脂肪變對肝病患者血清GP73水平的影響.方法 以100例健康體檢者為對照,觀察178例肝穿刺病理學檢查髮現肝脂肪變性患者的血清GP73水平差異.結果 與健康對照人群(35.61±12.22 ng/ml)相比,不同病因導緻的脂肪肝患者(70.62±60.60 ng/ml)血清GP73顯著升高.儘管酒精性脂肪肝(81.86±47.82 ng/ml)和急性肝損傷患者閤併肝細胞脂肪變(82.77±77.73 ng/ml)血清GP73水平略高于慢性乙型肝炎患者(63.84±50.62 ng/ml)和非酒精脂肪肝患者(65.75±62.20 ng/ml),但不同病因導緻的肝細胞脂肪變併未顯示血清GP73水平差異有統計學意義.更為重要的是,68例F≥1.0(71.46 ±66.48 ng/ml),75例F≥2.0(69.58±62.31ng/ml),以及34例F3-F4的患者(71.65±43.89 ng/ml),血清GP73的水平差異無統計學意義(F=0.02,P=0.98).相反,顯著性肝纖維化S≥2患者(91.04±82.37 ng/ml)其血清GP73水平顯著高于纖維化輕微S ＜2(65.80±53.45 ng/ml)的患者(P =0.029).結論 肝細胞脂肪變導緻血清GP73水平顯著升高,但肝細胞脂肪變的程度似乎與血清GP73水平無關.
목적 관찰불동병인간세포지방변대간병환자혈청GP73수평적영향.방법 이100례건강체검자위대조,관찰178례간천자병이학검사발현간지방변성환자적혈청GP73수평차이.결과 여건강대조인군(35.61±12.22 ng/ml)상비,불동병인도치적지방간환자(70.62±60.60 ng/ml)혈청GP73현저승고.진관주정성지방간(81.86±47.82 ng/ml)화급성간손상환자합병간세포지방변(82.77±77.73 ng/ml)혈청GP73수평략고우만성을형간염환자(63.84±50.62 ng/ml)화비주정지방간환자(65.75±62.20 ng/ml),단불동병인도치적간세포지방변병미현시혈청GP73수평차이유통계학의의.경위중요적시,68례F≥1.0(71.46 ±66.48 ng/ml),75례F≥2.0(69.58±62.31ng/ml),이급34례F3-F4적환자(71.65±43.89 ng/ml),혈청GP73적수평차이무통계학의의(F=0.02,P=0.98).상반,현저성간섬유화S≥2환자(91.04±82.37 ng/ml)기혈청GP73수평현저고우섬유화경미S ＜2(65.80±53.45 ng/ml)적환자(P =0.029).결론 간세포지방변도치혈청GP73수평현저승고,단간세포지방변적정도사호여혈청GP73수평무관.
Objective To explore the levels of serum GP73 in patients with fatty liver disease.Methods The sera GP73 were determined by ELISA in 178 patients with fatty liver disease and 100 healthy controls.Results Serum GP73 levels were significantly increased in patients with various fatty liver diseases(70.62 ± 60.60 ng/ml),compared with those of control population (35.61 ± 12.22 ng/ml).In patients with alcoholic fatty liver disease,acute liver injury,chronic hepatitis B,and non-alcoholic fatty liver disease,their serum GP73 concentration were 81.86 ±47.82 ng/ml,82.77 ±77.73 ng/ml,63.84 ±50.62 ng/ml,and 65.75 ± 62.20 ng/ml,respectively.But no significant difference was found between these groups (P ＞ 0.05).In 68 patients with F ≥ 1.0 (71.46 ± 66.48 ng/ml),75 patients with F ≥ 2.0(69.58 ± 62.31 ng/ml),and 34 patients with F3-F4 (71.65 ± 43.89 ng/ml),there were also no marked differences was observed between these fatty groups (F =0.02,P =0.98).Conclusion Serum GP73 levels were increased in patients with different liver diseases,but its concentrations were seems not related with degree of fatty injury.
