中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2013年
4期
277-279
,共3页
刘晓玲%李孟磊%马文霞%夏胜利%许汴利
劉曉玲%李孟磊%馬文霞%夏勝利%許汴利
류효령%리맹뢰%마문하%하성리%허변리
培菲康%儿童,学龄前%腹泻
培菲康%兒童,學齡前%腹瀉
배비강%인동,학령전%복사
BIFICO%Child,preschool%Diarrhea
目的 研究益生菌(培菲康散剂,BIFICO)对1~6岁婴幼儿腹泻发病的影响及预防作用.方法 490例要幼儿按年龄分层招募后被分为两组:试验组(n =247)和对照组(n=243).以随机、双盲、安慰剂对照为原则,给予合格的受试者口服临床研究专用培菲康散剂.受试者连续服用试验用药4天、随访观察21天为一个周期,共进5个周期.研究期内遵循“逢泻必检”原则,对受试儿童随访并采集腹泻婴幼患儿的粪便标本,进行病原学检测,评价预防效果.结果 共有480名完成全部实验.对照组和实验组分别有120人次和95人次发生腹泻,腹泻发生率分别为50.85%和38.93%,差异具有统计学意义(x2 =4.175,P=0.041).以观察周期分组后,第3周期对照组婴幼儿腹泻发病率显著高于实验组(x2 =4.415,P=0.036).从腹泻要幼儿粪便中共检出轮状病毒14株、诺如病毒3株、扎如病毒3株、腺病毒2株,另外检出沙门菌5株、细菌性痢疾4株.结论 口服培菲康散剂可降低1~6岁婴幼儿腹泻发病率,对腹泻具有一定的预防作用.
目的 研究益生菌(培菲康散劑,BIFICO)對1~6歲嬰幼兒腹瀉髮病的影響及預防作用.方法 490例要幼兒按年齡分層招募後被分為兩組:試驗組(n =247)和對照組(n=243).以隨機、雙盲、安慰劑對照為原則,給予閤格的受試者口服臨床研究專用培菲康散劑.受試者連續服用試驗用藥4天、隨訪觀察21天為一箇週期,共進5箇週期.研究期內遵循“逢瀉必檢”原則,對受試兒童隨訪併採集腹瀉嬰幼患兒的糞便標本,進行病原學檢測,評價預防效果.結果 共有480名完成全部實驗.對照組和實驗組分彆有120人次和95人次髮生腹瀉,腹瀉髮生率分彆為50.85%和38.93%,差異具有統計學意義(x2 =4.175,P=0.041).以觀察週期分組後,第3週期對照組嬰幼兒腹瀉髮病率顯著高于實驗組(x2 =4.415,P=0.036).從腹瀉要幼兒糞便中共檢齣輪狀病毒14株、諾如病毒3株、扎如病毒3株、腺病毒2株,另外檢齣沙門菌5株、細菌性痢疾4株.結論 口服培菲康散劑可降低1~6歲嬰幼兒腹瀉髮病率,對腹瀉具有一定的預防作用.
목적 연구익생균(배비강산제,BIFICO)대1~6세영유인복사발병적영향급예방작용.방법 490례요유인안년령분층초모후피분위량조:시험조(n =247)화대조조(n=243).이수궤、쌍맹、안위제대조위원칙,급여합격적수시자구복림상연구전용배비강산제.수시자련속복용시험용약4천、수방관찰21천위일개주기,공진5개주기.연구기내준순“봉사필검”원칙,대수시인동수방병채집복사영유환인적분편표본,진행병원학검측,평개예방효과.결과 공유480명완성전부실험.대조조화실험조분별유120인차화95인차발생복사,복사발생솔분별위50.85%화38.93%,차이구유통계학의의(x2 =4.175,P=0.041).이관찰주기분조후,제3주기대조조영유인복사발병솔현저고우실험조(x2 =4.415,P=0.036).종복사요유인분편중공검출륜상병독14주、낙여병독3주、찰여병독3주、선병독2주,령외검출사문균5주、세균성이질4주.결론 구복배비강산제가강저1~6세영유인복사발병솔,대복사구유일정적예방작용.
Objective To investigate the prevention of diarrhea by oral BIFICO for infants aged 1-6 years.Methods 490 cases of infants were randomly divided after age stratification:the experimental group (n =247) and the control group (n =243).Based on principles of randomized double-blind and placebocontrolled,the infants were given BIFICO(dedicated clinical research)therapy for 4 consecutive days,then observed for 21 days.25 days composed a cycle.They were observed total 5 cycles.During the study period,principles for "the diarrhoea patients must be detected",follow-up visited the participant infants and conducted etiology detection by way of sampling for diarrhea infants.Evaluate the prevention efficacy of diarrhea by oral BIFICO for infants aged 1-6 years.Results A total of 480 completed all study.120 and 95 infants in the control group and experimental group were detected with diarrhea.The incidence of diarrhea was 50.85% and 38.93% in these two guoup,respectively.The difference has statistical significance (x2 =4.175,P =0.041).In the third observation period,the infants in the control group had a higer incidence of diarrhea compared with which in the experimental grouP(x2 =4.415,P =0.036).14 strains of rotavirus,3 strains of norovirus,3 strains of sappovirus,2 strains of adenovirus,5 strains of salmonella and 4 strains of Shigella were check out in 128 samples.Conclusion Oral BIFICO can paly certain preventive role on diarrhea,and decrease the incidence of diarrhea in infants aged 1-6 years.