CAJ | 학술논문

目的通过检测血清中HBV-LP、HBV DNA、Pre-S1和HBV血清标志物,探讨HBV-LP对于反映HBV病毒复制和抗病毒疗效评估的意义.方法采用ELISA法对220份血清标本进行HBV-LP、Pre-S1和HBV血清标志物检测,采用荧光PCR方法检测血清中HBV DNA含量.采用阿德福韦酯进行抗病毒治疗,在12周、24周、36周和48周进行各项血清学指标监测.结果在慢性乙肝患者中,HBV-LP检出率与HBV DNA检出率差异无统计学意义,且显著高于Pre-S1和HBeAg检出率,在HBeAg阴性患者中HBV-LP与HBV DNA检出率相仿,在抗病毒治疗过程中,HBV-LP与HBV DNA降低趋势一致.结论 HBV-LP能够反映出HBV复制情况,是良好的慢性乙肝诊断和疗效评估指标.
목적 통과검측혈청중HBV-LP、HBV DNA、Pre-S1화HBV혈청표지물,탐토HBV-LP대우반영HBV병독복제화항병독료효평고적의의.방법 채용ELISA법대220빈혈청표본진행HBV-LP、Pre-S1화HBV혈청표지물검측,채용형광PCR방법검측혈청중HBV DNA함량.채용아덕복위지진행항병독치료,재12주、24주、36주화48주진행각항혈청학지표감측.결과 재만성을간환자중,HBV-LP검출솔여HBV DNA검출솔차이무통계학의의,차현저고우Pre-S1화HBeAg검출솔,재HBeAg음성환자중HBV-LP여HBV DNA검출솔상방,재항병독치료과정중,HBV-LP여HBV DNA강저추세일치.결론 HBV-LP능구반영출HBV복제정황,시량호적만성을간진단화료효평고지표.
Objective To explore the sigificance of HBV-LP in the HBV replication and anti-virus treatment efficacy assessment by detect the serum HBV-LP and HBV DNA and Pre-S1 and HBV serum markers.Methods Serum HBV-LP,Pre-S1 and HBV serologic markers were measured by enzyme-linked immunosobent assay(ELISA),fluorescent PCR method to detect serum HBV DNA content in the 220 cases infected serum of CHB.Treated with adefovir dipivoxil antiviral therapy,and mesured the setologic indicators after 12 weeks,24 weeks,36 weeks and 48 weeks.Results The detection rate of HBV-LP and HBV DNA detection rate no significant difference in patients with chronic hepatitis B,and significantly higher than the Pre-S1 and HBeAg detection rate.HBV-LP positive rate also similar to the HBV DNA positive rate in HBeAg negative CHB patients.In the anti-virus therapy,the declined of HBV-LP similar to HBV DNA.Conclusions HBV-LP can reflect the HBV replication,is a good chronic hepatitis B diagnosis and efficacy evaluation index.