CAJ | 학술논문

目的探讨早期、足量应用甲基强的松龙联合丙种免疫球蛋白治疗重症手足口病的临床疗效.方法将568例重症手足口病患儿随机分为2组,A组给予早期足量应用甲基强的松龙联合丙种免疫球蛋白治疗,B组给予常规治疗,两组同时配合对症、支持、控制颅内压等治疗.结果 A 组治愈率高于B组,危重型发生率低于B组,且在发热、皮疹、神经系统症状、肺炎表现、白细胞增高的控制方面优于B组,并未增加治疗相关的近期、远期不良反应.结论早期、足量实用甲基强的松龙联合丙种免疫球蛋白治疗重症手足口病有效、安全,值得在临床工作中进一步推广.
목적 탐토조기、족량응용갑기강적송룡연합병충면역구단백치료중증수족구병적림상료효.방법 장568례중증수족구병환인수궤분위2조,A조급여조기족량응용갑기강적송룡연합병충면역구단백치료,B조급여상규치료,량조동시배합대증、지지、공제로내압등치료.결과 A 조치유솔고우B조,위중형발생솔저우B조,차재발열、피진、신경계통증상、폐염표현、백세포증고적공제방면우우B조,병미증가치료상관적근기、원기불량반응.결론 조기、족량실용갑기강적송룡연합병충면역구단백치료중증수족구병유효、안전,치득재림상공작중진일보추엄.
Objective To study the efficacy of early,enough methylprednisone combined with immunoglobulin in treatments of severe hand-foot-mouth disease.Methods 568 patients of severe handfoot-mouth disease involved were randomized into group A and group B.Patients of both groups all accepted symptomatic treatment,supportive therapy and the treatment of control intracranial pressure.And patients in group A received the treatment of early,enough methylprednisone combined with immunoglobulin,whereas patients in group B received conventional therapy.Results Curative rate of group A was better than that of group B,otherwise incidence rate of critical illness was less than that of group B.The control time of fever,erythra,neurological symptoms,features of pneumonia and increased leukocyte of group A was shorter than that of group B,and no more recent or Long-term treatment-related adverse reaction in group A.Conclusion Early,enough methylprednisone combined with immunoglobulin is effective,safe in treating severe handfoot-mouth disease,and worthy to recommand its clinical use.