CAJ | 학술논문

目的分析血清脂联素水平在乳腺癌患者与非肿瘤女性之间的差异以及血清脂联素水平改变与乳腺癌临床特征的关系,探讨脂联素在乳腺癌发病中的作用.方法采用酶联免疫吸附试验(ELISA)方法检测脂联素在46例女性乳腺癌患者和35例非肿瘤女性外周血清中的浓度,并进行统计学分析.分析血清脂联素水平改变与乳腺癌患者绝经前后、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)、病理分级和淋巴结转移等临床特征的关系.结果女性乳腺患者血清脂联素水平较非肿瘤女性组显著降低[(6.098±1.460)比(8.691±1.883),差异有统计学意义(P＜0.01)].绝经前女性血清脂联素水平明显低于绝经后女性血清脂联素水平.绝经前的乳腺癌女性患者较非肿瘤组绝经前女性血清脂联素水平显著降低,同时绝经后的乳腺癌女性患者较非肿瘤组绝经后女性血清脂联素水平显著降低.肿瘤直径＞2 cm的患者脂联素水平均较肿瘤直径≤2 cm的患者显著降低.肿瘤组织学分级Ⅱ和Ⅲ级的患者脂联素水平较肿瘤组织学分级1级的患者显著降低.有无淋巴结转移对患者的脂联素水平影响差异无统计学意义(P＞0.05).而外周血清脂联素水平与乳腺癌患者ER及PR无明显相关.结论乳腺癌患者血清脂联素水平显著降低,而这一改变不依赖于年龄、绝经前后、体质量指数等指标.低脂联素水平的乳腺癌患者肿瘤的恶性度更高.
목적 분석혈청지련소수평재유선암환자여비종류녀성지간적차이이급혈청지련소수평개변여유선암림상특정적관계,탐토지련소재유선암발병중적작용.방법 채용매련면역흡부시험(ELISA)방법검측지련소재46례녀성유선암환자화35례비종류녀성외주혈청중적농도,병진행통계학분석.분석혈청지련소수평개변여유선암환자절경전후、종류대소、자격소수체(ER)、잉격소수체(PR)、병리분급화림파결전이등림상특정적관계.결과 녀성유선환자혈청지련소수평교비종류녀성조현저강저[(6.098±1.460)비(8.691±1.883),차이유통계학의의(P＜0.01)].절경전녀성혈청지련소수평명현저우절경후녀성혈청지련소수평.절경전적유선암녀성환자교비종류조절경전녀성혈청지련소수평현저강저,동시절경후적유선암녀성환자교비종류조절경후녀성혈청지련소수평현저강저.종류직경＞2 cm적환자지련소수평균교종류직경≤2 cm적환자현저강저.종류조직학분급Ⅱ화Ⅲ급적환자지련소수평교종류조직학분급1급적환자현저강저.유무림파결전이대환자적지련소수평영향차이무통계학의의(P＞0.05).이외주혈청지련소수평여유선암환자ER급PR무명현상관.결론 유선암환자혈청지련소수평현저강저,이저일개변불의뢰우년령、절경전후、체질량지수등지표.저지련소수평적유선암환자종류적악성도경고.
Objective To explore the role of Adiponectin (ADPN) in the development of breast cancer by analyzing the change in serum ADPN levels in the female patients with breast cancer and the relationship between the serum ADPN levels and the clinicopathological characteristics of breast cancers.Methods Serum ADPN levels were measured by using enzyme linked immunosorbent assay (ELISA) in 64 cases of breast cancer and 35 healthy controls.The relationship between serum ADPN levels and clinicopathological characteristics of breast cancer including age,tumor size,estrogen receptor (ER),progesterone receptor (PR),menopause status,pathological grade,and lymph node metastasis was examined.Results As compared with the healthy controls,serum ADPN levels in the patients were significantly reduced (6.098 ± 1.460 vs.8.691 ± 1.883,P ＜0.01).The serum ADPN levels in in the premenopausal women were significantly decreased as compared with the postmenopausal women.The serum ADPN levels in the tumors with the diameter of ＞ 2 cm and those in the tumors with histological grade of Ⅱ + Ⅲ were significantly lower.Conclusion The serum ADPN levels in the patients with breast cancer are significantly reduced,which is independent of age,menopause status,BMI,and hormone receptor status.Tumors arising in women with the low serum ADPN levels are more likely to show a biologically aggressive phenotype.